Peptides Mimicking the β7/β8 loop of HIV-1 Reverse Transcriptase p51 as “Hotspot-Targeted” Dimerization Inhibitors

Corona, Angela;Tramontano, Enzo;
2020-01-01

Abstract

A conformationally constrained short peptide designed to target a protein-protein interaction hotspot in HIV-1 reverse transcriptase (RT) disrupts p66-p51 interactions and paves the way to the development of novel RT dimerization inhibitors.
2020
Inglese
ACS MEDICINAL CHEMISTRY LETTERS
11
5
811
817
7
WOS:000535281200031
2-s2.0-85081654425
32435389
https://pubs.acs.org/doi/10.1021/acsmedchemlett.9b00623
Esperti anonimi
internazionale
scientifica
Peptides; Hot spot mimics; Dimerization inhibitors; HIV-1 RT inhibitors
sì
Sánchez-Murcia, Pedro A.; de Castro, Sonia; García-Aparicio, Carlos; Jimenez, M. Angeles; Corona, Angela; Tramontano, Enzo; Sluis-Cremer, Nicolas; Men ...espandi
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
11
reserved
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