Complex formation equilibria of polyamine ligands with copper(II) and zinc(II)

Nurchi, Valeria M.
;
Crisponi, Guido;Sanna, Gavino;
2019-01-01

Abstract

A comprehensive study of the protonation equilibria of a series of polyamine ligands along with their complex formation equilibria with Cu 2+ and Zn 2+ is reported in this work. The primary aim of this study has been the achievement of homogeneous thermodynamic data on these ligands, in order to evaluate their influence on the homeostatic equilibria of essential metal ions (Cu 2+ and Zn 2+ ) in biological fluids. These polyamines are largely used as linkers in the building of chelating agents for iron overload. Potentiometric and spectrophotometric techniques were used for the characterization of protonation and complex formation constants. In addition, the characterization of the formed complexes is discussed together with selected solid-state crystal structures, remarking the influence of the length of the chain and of the linear or tetradentate tripod nature of the polyamine ligands on the stability of the complexes.
2019
Inglese
194
26
33
8
www.elsevier.com/locate/jinorgbio
Esperti anonimi
internazionale
scientifica
Complex formation constant; Crystal structures; Potentiometry; Protonation constant; UV–visible spectrophotometry; Biochemistry; Inorganic Chemistry
Nurchi, Valeria M.; Crisponi, Guido; Sanna, Gavino; Pérez-Toro, Inmaculada; Niclos-Gutierrez, Juan; Gonzalez-Perez, Maria Josefa; Domínguez Martín, Al ...espandi
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
7
reserved
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