Essential thrombocytemia following immune thrombocytopenia with JAK2V617F mutation
Caocci, Giovanni
First
;USAI, MONICA;La Nasa, GiorgioLast
2018-01-01
Abstract
JAK2V617Fmutation is found in about 60% of cases of essential thrombocytemia (ET) and represents a driving mutation. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by a low platelet (PLT) count. So far, only 2 reports described ET following ITP. For the first time we analyzed in a patient the JAK2V617Fallele burden at ITP onset occurred 13 years before the ET diagnosis and found the presence of a small clone JAK2V617Fpositive clone (3%) raised to 27% in the following years. The association of ET and ITP could suggest similar pathogenetic mechanisms that should be further investigated.File | Size | Format | |
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