Catalytic enantioselective synthesis of α-(benzylamino)cyclobutanones
MELIS, NICOLA;GHISU, LORENZA;CABONI, PIERLUIGI;SECCI, FRANCESCO;FRONGIA, ANGELO
2015-01-01
Abstract
An organocatalytic enantioselective synthesis of α-(benzylamino)cyclobutanones has been achieved by employing a tandem condensation/intramolecular rearrangement/proton transfer reaction and starting from racemic α-hydroxycyclobutanone and a selection of benzylamines. This reaction sequence afforded the products in good to high yields with moderate to high enantioselectivities.File | Size | Format | |
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