QUALIFICA:

Dal 2002: Professore di prima fascia di Farmacologia, Università di Cagliari.

STUDI E FORMAZIONE:

1975: Laurea in Medicina summa cum laude, Università di Buenos Aires (Laurea convalidata nel 1985 presso l’Università di Cagliari).

1976-1981: Borsista del Consiglio Nazionale delle Ricerche (CONICET) presso l’Instituto de Investigaciones Farmacologicas, Buenos Aires, Argentina.

1981-1983: Visiting fellow – Laboratory of Preclinical Pharmacology, St. Elizabeth’s Hospital, NIH, Washington DC, USA.

1985-1989: Professore a Contratto di Biotecnologie, Università di Cagliari.

1990: Ricercatore Universitario, SSD BIO 14 – Farmacologia, Università di Cagliari.

1995-1996: Visiting scientist – Laboratory of Neurophysiology, NINDS – NIH, Bethesda, MD – U.S.A.

1998: Professore Associato, SSD BIO 14 – Farmacologia, Università di Cagliari.

SOCIETÀ SCIENTIFICHE

Society for Neuroscience (U.S.A.)

International Behaviour and Neural Genetics Society (membro del comitato esecutivo)

International Brain Research Organization   FENS

ATTIVITÀ EDITORIALE

Revisore: Behavior Genetics, Behavioral Brain Research, Brain Research, European Journal of Neuroscience, Journal of Neurochemistry, Neuropsychopharmacology, Pharmacology Biochemistry and Behavior.

Membro dell’Editorial Board del World Journal of Neuroscience, 2014.

REVISIONE DI PROGETTI DI RICERCA

Membro dell’Albo dei revisori MIUR- COFIN, 2005

 

ELENCO DI PUBBLICAZIONI SELEZIONATE

S.Z. Langer, E. Adler-Graschinsky and O. Giorgi.  Physiological significance of alpha-adrenoceptor mediated feed-back mechanism regulating noradrenaline release during nerve stimulation. Nature, 265: 648-650, 1977.

O.Giorgi and M.C. Rubio. Decreased 3H-L-quinuclidinyl benzilate binding and muscarinic receptor subsensitivity after chronic gamma-butyrolactone treatment. Naunyn-Schmiedeberg’s Arch. Pharmacol., 318: 14-18, 1981.

J.L. Meek, M.J. Iadarola and O. Giorgi.  Cholecystokinin turnover in brain. Brain Res., 276: 375-378, 1983.

O.Giorgi and J.L. Meek. Gamma-aminobutyric acid turnover in rat striatum: effects of glutamate and kainic acid. J. Neurochem., 42: 215-220, 1984.

A. Leon, D. Benvegnú, R. Dal Toso, D. Presti, L. Facci, O. Giorgi and G. Toffano.  Dorsal root ganglia and nerve growth factor: a model for understanding the mechanism of GM1 effect on neuronal repair. J. of Neurosci. Res., 12: 277-287, 1984.

O.Giorgi and J.L. Meek. Sulfation of peptides and simple phenols by rat brain sulfotransferase: inhibition by dichloronitrophenol. Biochem. Pharmacol., 34: 45-49, 1985.

I. Mocchetti, O. Giorgi, J.P. Schwartz and E. Costa.  A reduction of the tone of 5-hydroxytryptamine neurons decreases utilization rates of striatal and hypothalamic enkephalins. Eur. J. Pharmacol., 106: 427-430, 1985.

M.G. Corda, O. Giorgi, F. Gatta and G. Biggio.  Long-lasting proconflict effect induced by chronic administra­tion of the beta-carboline derivative FG 7142. Neurosci. Lett. 62: 237-240, 1985.

M.G. Corda, E. Sanna, A. Concas, O. Giorgi, E. Ongini, V. Nurchi, T. Pintori, G. Crisponi and G. Biggio.  Enhancement of GABA binding by quazepam, a benzodiazepine derivative with preferential affinity for Type I benzodiazepine receptors. J. Neurochem., 47: 370-374, 1986.

M.L. Porceddu, O. Giorgi, E. Ongini, S. Mele and G. Biggio.  3H-SCH 23390 binding sites in the rat substantia nigra: evidence for a presynaptic localization and innervation by dopamine. Life Sci., 39: 321-328, 1986.

M.G. Corda, O. Giorgi and G. Biggio.  Behavioral and biochemical evidences for a long-lasting decrease in GABAergic function elicited by chronic administration of FG 7142. Brain Res., 384: 60-67, 1986.

O.Giorgi, M.G. Corda and G. Biggio. The anxiolytic beta-carboline ZK 93423 prevents the stress-induced increase in dopamine turnover in the prefrontal cortex. Eur. J. of Pharmacol., 134: 327-331, 1987.

G.P. Mereu, M.G. Corda, P. Carcangiu, O. Giorgi and G. Biggio. The beta-carboline ZK 93423 inhibits reticulata neurons: an effect reversed by benzodiazepine antagonists. Life Sci., 40: 1423-1430, 1987.

M.G. Corda, O. Giorgi, B. Longoni, G.P. Mereu and G. Biggio.  Enhancement of gamma-aminobutyric acid binding by the anxiolytic beta-carbolines ZK 93423 and ZK 91296. J. Neurochem., 48: 1355-1358, 1987.

M.L. Porceddu, O. Giorgi, G. De Montis, S. Mele, L. Cocco, E. Ongini and G. Biggio.  6-hydroxydopamine-induced degeneration of nigral dopamine neurons: differential effect on nigral and striatal D-1 dopamine receptors. Life Sci., 41: 697-706, 1987.

O. Giorgi, G. Calderini, G. Toffano and G. Biggio. D-1 dopamine receptors labelled with 3H-SCH 23390: decrease in the striatum of aged rats. Neurobiology of Aging, 8: 51-54, 1987.

M.G. Corda, O. Giorgi, S. Mele and G. Biggio.  Enhanced sensitivity to beta-carboline inverse agonists in rats chronically treated with FG 7142. Brain Res. Bull., 19: 379-385, 1987.

O. Giorgi, G. De Montis, M.L. Porceddu, S. Mele, G. Calderini, G. Toffano and G. Biggio. Developmental and age-related changes in D-1 dopamine receptors and dopamine content in the rat striatum. Dev. Brain Res., 35: 283-290, 1987.

M.G. Corda, O. Giorgi, B. Longoni, E. Ongini, S. Montaldo and G. Biggio. Preferential affinity of 3H-2-oxo-quazepam for Type I benzodiazepine recognition sites in the human brain. Life Sci., 42: 189-197, 1987.

M.G. Corda, O. Giorgi, B. Longoni, E. Ongini, A. Barnett, S. Montaldo and G. Biggio.  GABA and pentobarbital enhance 3H-2-oxo-quazepam binding to Type I benzodiazepine recognition sites in rat and human brain. J. Neurochem., 50: 681-687, 1988.

M.G. Corda, O. Giorgi, B. Longoni, E. Ongini, S. Montaldo and G. Biggio.  Characterization of 3H-2-oxo-quazepam binding in the human brain. Progress in Neuropsychopharmacol. and Biol. Psychiatry, 12: 701-712, 1988.

M.G. Corda, O. Giorgi, B. Longoni and G. Biggio.  Decreased sensitivity to diazepam induced by chronic administration of FG 7142. Neurosci. Lett., 86: 219-224, 1988.

O. Giorgi, M.G. Corda, A. Fernández and G. Biggio. The abstinence syndrome in diazepam-dependent cats is precipitated by Ro 15-1788 and Ro 15-4513 but not by the benzodiazepine receptor antagonist ZK 93426. Neurosci. Lett. 88: 206-210, 1988.

Dal Toso, O. Giorgi, C. Soranzo, G. Kirschner, G. Ferrari, M. Favaron, D. Benvegnú, D. Presti, S. Vicini,G. Toffano, G.F. Azzone and A. Leon. Development and survival of neurons in dissociated fetal mesencephalic serum-free cell cultures: effects of cell density and of an adult mammalian striatal derived neuronotrophic factor (SDNF). J. Neurosci., 8: 733-745, 1988.

O. Giorgi, M.G. Corda and G. Biggio. Ro 15-4513, like anxiogenic beta-carbolines, increases dopamine metabolism in the prefrontal cortex of the rat. Eur. J. Pharmacol., 156: 71-76, 1988.

F. Marrosu, G. Mereu, O. Giorgi and M.G. Corda. The benzodiazepine recognition sites inverse agonists Ro 15-4513 and FG 7142 both antagonize the EEG effects of ethanol in the rat. Life Sci., 43: 2151-2158, 1988.

O. Giorgi, M.G. Corda, A. Fernández and G. Biggio. The beta-carboline derivatives ZK 93426 and FG 7142 fail to precipitate abstinence signs in diazepam-dependent cats. Pharmacol. Biochem. Behav., 32, 671-675, 1989.

M.G. Corda, O. Giorgi, B. Longoni and G. Biggio.  Ro 15-4513, a partial inverse agonist for benzodiazepine recognition sites, has proconflict and proconvulsant effects in the rat. Eur. J. Pharmacol., 159: 233-239, 1989.

O. Giorgi, M.G. Corda, I. Gritti, M. Mariotti, E. Ongini and G. Biggio. Binding sites for 3H-2-oxo-quazepam in the brain of the cat: evidence for heterogeneity of benzodiazepine recognition sites. Neuropharmacol., 28: 715-718, 1989.

M.G. Corda, O. Giorgi, B. Longoni, E. Ongini, G. Pesce, R. Cruciani and G. Biggio. Functional coupling of GABAA receptors and benzodiazepine recognition site subtypes in the spinal cord of the rat. Eur. J. Pharmacol., 169: 205-213, 1989.

O. Giorgi and G. Biggio. Unilateral inactivation of dopamine receptors after intrastriatal injection of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ): A novel rotational model to investigate dopamine receptor interactions. Pharmacol. Biochem. Behav., 35: 877-884, 1990.

O. Giorgi, M.L. Porceddu, S. Pepitoni, G.P. Serra, G. Toffano and G. Biggio. Differential effect of aging on 3H-SCH 23390 binding sites in the retina and in distinct areas of the rat brain. J. Neural Transmission, 82: 157-166, 1990.

M.G. Corda, O. Giorgi, B. Longoni, M. Orlandi and G. Biggio. Decrease in the function of the GABA-coupled chloride channel produced by the repeated administration of pentylenetetrazol to rats. J. Neurochem., 55: 1216-1221, 1990.

O. Giorgi and G. Biggio. Selective unilateral inactivation of striatal D-1 and D-2 dopamine receptor subtypes by EEDQ: turning behavior elicited by D-2 dopamine receptor agonists. Brain Res., 533: 53-59, 1990.

G. Biggio, A. Concas, M.G. Corda, O. Giorgi, E. Sanna and M. Serra. GABAergic and dopaminergic transmission in the rat cerebral cortex: effect of stress, anxiolytic and anxiogenic drugs. Pharmacology and Therapeutics, 48: 121-142, 1990.

O. Giorgi, M. Orlandi, D. Lecca and M.G. Corda. MK-801 prevents chemical kindling induced by pentylenetetrazol in rats. Eur. J. Pharmacol., 193: 363-365, 1991.

O. Giorgi, M.G. Pibiri, E. Ongini, M. Trampus and G. Biggio. The neutral endopeptidase-24.11 (enkephalinase) inhibitor, SCH 32615, increases dopamine metabolism in the nucleus accumbens of the rat. Eur. J. Pharmacol. 194: 17-23, 1991.

O. Giorgi, M.G. Pibiri and G. Biggio. Differential turnover rates of D1 dopamine receptors in the retina and in distinct areas of the rat brain. J. Neurochem., 57: 754-759, 1991.

M.G. Corda, M. Orlandi, D. Lecca and O. Giorgi.  Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors. Pharmacol. Biochem. Behav., 40: 329-333, 1991.

M.G. Corda, M. Orlandi, A.M. Deiana, S. Salvadori and O. Giorgi. Age-related decrease in the density of benzodiazepine recogni­tion sites in the brain of the fresh water eel (Anguilla anguilla). Neurosci. Lett., 133: 168-170, 1991.

O. Giorgi, M. Orlandi, M. Geic and M.G. Corda. MK-801 prevents the decrease in 35S-TBPS binding in the rat cerebral cortex induced by pentylenetetrazol kindling. Brain Res. Bull., 27: 835-837, 1991.

O. Giorgi, M.G. Pibiri, R. Dal Toso and G. Ragatzu. Age-related changes in the turnover rates of D1 dopamine receptors in the retina and in distinct areas of the rat brain. Brain Res., 569: 323-329, 1992.

M.G. Corda, M. Orlandi, D. Lecca and O. Giorgi.  Decrease in GABAergic function induced by pentylenetetrazol kindling in rats: antagonism by MK-801. J. Pharmacol. Exp. Ther., 262: 792-800, 1992.

O. Giorgi, M.G. Pibiri, R. Loi and M.G. Corda. Chronic treatment with SCH 23390 increases the production rate of D1 dopamine receptors in the nigro-striatal system of the rat. Eur. J. Pharmacol., 245: 139-145, 1993.

M.G. Corda, E. Cancedda and O. Giorgi.  Modulation of 35S-t-butylbicyclophosphorothionate binding by ligands for the benzodiazepine receptor in newborn and adult rats: Influence of gamma-aminobutyric acid. Brain Res. Bull., 32: 647-652, 1993.

O. Giorgi, M. Orlandi, R.M. Escorihuela, P. Driscoll, D. Lecca and M.G. Corda. GABAergic and Dopaminergic transmission in the brain of Roman high-avoidance and Roman low-avoidance rats. Brain Res., 638: 133-138, 1994.

O. Giorgi, E. Cancedda, D. Lecca, M. Orlandi and M. G. Corda. Allosteric Modulation of 35S-TBPS binding in the cerebral cortex of the rat during postnatal development. Dev. Brain Res., 80: 73-80, 1994.

O. Giorgi, A.M. Deiana, S. Salvadori, D. Lecca and M.G. Corda. Developmental changes in the content of dopamine in the olfactory bulb of the european eel (Anguilla anguilla). Neurosci. Lett., 172: 35-38, 1994.

O. Giorgi, D. Lecca, E. Cancedda, G.P. Serra and M.G. Corda. Modulation of [35S]TBPS binding by ligands with preferential affinity for benzodiazepine BZ1 sites in the cerebral cortex of newborn and adult rats. Eur. J. Pharmacol., 290: 37-47, 1995.

Ferré, A. Fernández-Teruel, R.M. Escorihuela, P. Driscoll, M.G. Corda, O. Giorgi, and A. Tobeña. Behavior of the Roman-Verh high- and low- avoidance rat lines in anxiety tests: relationship with defecation and self-grooming. Physiol. and Behavior, 58: 1209-1213, 1995.

O. Giorgi, M. Orlandi, D. Lecca, G.P. Serra, L. Zhang and M.G. Corda. Kinetics of tert-[35S]butylbicyclophosphorothionate binding in the cerebral cortex of newborn and adult rats: Effects of GABA and receptor desensitization. J. Neurochem., 67: 423-429, 1996.

O. Giorgi, G. Carboni, V. Frau, M. Orlandi, V. Valentini, A. Feldman and M.G. Corda. Anticonvulsant effect of felbamate in the pentylenetetrazole kindling model of epilepsy in the rat. Naunyn-Schmiedeberg’s Arch. Pharmacol., 354: 271-276, 1996.

L. Zhang, J.L. Barker, G. Xing, O. Giorgi, W. Ma, Y.H. Chang, Q. Hu, N. Choi, and D.R. Rubinow. 5-HT1A receptor mRNA expressions differ in the embryonic spinal cord of male and female rats. Neurosci. Lett., 237: 41-44, 1997.

M.G. Corda, D. Lecca, G. Piras, G. Di Chiara, and O. Giorgi.  Biochemical parameters of dopaminergic and GABAergic neurotransmission in the CNS of Roman high-avoidance and Roman low-avoidance rats. Behavior Genetics, 27: 527-536, 1997.

O. Giorgi, M.G. Corda, G. Carboni, V. Frau, and G. Di Chiara. Effects of cocaine and morphine in rats from two psychogenetically selected lines: A behavioral and brain dialysis study. Behavior Genetics, 27: 537-546, 1997.

P. Driscoll, R.M. Escorihuela, A. Fernández-Teruel, O. Giorgi, H. Schwegler, T. Steimer, A. Wiersma, M.G. Corda, J. Flint, J.M. Koolhaas, W. Langhans, P.E. Schulz, J. Siegel, and A. Tobeña. Genetic selection and differential stress responses: The Roman lines/strains of rats.  Ann. N.Y. Acad. Sci., 851: 501-510, 1998.

H. Viola, M. Marder, C. Wasowski, O.Giorgi, A.C.Paladini and J. H. Medina. 6, 3?- Dibromoflavone and 6- nitro- 3?- bromoflavone: New additions to the 6, 3?- disubstituted flavone family of high-affinity ligands of the brain benzo-diazepine binding site with agonistic properties. Biochem. Biophys. Res. Commun., 273: 694-698, 2000.

O. Giorgi, G. Piras, D. Lecca, S. Hansson, P. Driscoll and M.G. Corda. Differential neurochemical properties of central serotonergic transmission in Roman high- and low-avoidance rats. J Neurochem., 86: 422-431, 2003.

O. Giorgi, D. Lecca, G. Piras, P. Driscoll and M.G. Corda. Dissociation between mesocortical dopamine release and fear-related behaviours in two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions. Eur. J. Neurosci., 17: 2716-2726, 2003.

G. Piras, D. Lecca, M.G. Corda and O. Giorgi. Repeated morphine injections induce behavioural sensitization in Roman high-, but not in Roman low-avoidance rats. Neuroreport, 14: 2483-2488, 2003.

D. Lecca, G. Piras, P. Driscoll, O. Giorgi and M.G. Corda. A differential activation of dopamine output in the shell and core of the nucleus accumbens is associated with the motor responses to addictive drugs: A brain dialysis study in Roman high- and low-avoidance rats. Neuropharmacology, 46: 688-699, 2004.

M.G. Corda , G. Piras, D. Lecca, A. Fernández-Teruel, P. Driscoll and O. Giorgi.  The psychogenetically selected Roman rat lines differ in the susceptibility to develop amphetamine sensitization. Behav. Brain Res., 157: 147-156, 2005.

O. Giorgi, G. Piras, D. Lecca and M.G. Corda. Behavioural effects of acute and repeated cocaine treatments: A comparative study in sensitisation-prone RHA rats and their sensitisation-resistant RLA counterparts. Psychopharmacology, 180: 530-538, 2005.

O. Giorgi, D. Lecca G. Piras and M.G. Corda. Differential activation of dopamine release in the nucleus accumbens core and shell after acute or repeated amphetamine injections: A comparative study in the Roman high- and low-avoidance rat lines. Neuroscience, 135: 987-998, 2005.

M.G. Corda, G. Piras and O. Giorgi.  Neonatal ventral hippocampal lesions potentiate amphetamine-induced increments in dopamine efflux in the core, but not shell, of the nucleus accumbens. Biol. Psychiatry, 60: 1188-1195, 2006.

O. Giorgi, G. Piras, M.G. Corda. The psychogenetically selected Roman high- and low-avoidance rat lines: A model to study the individual vulnerability to drug addiction. Neurosci Biobehav Rev., 31: 148-163, 2007.

L. Fattore, G. Piras, M.G. Corda, O. Giorgi. The Roman high- and low-avoidance rat lines differ in the acquisition, maintenance, extinction and reinstatement of intravenous cocaine self-administration. Neuropsychopharmacol., 34: 1091-1101, 2009. (doi: 10.1038/npp.2008.43).

G. Piras, O. Giorgi, M.G. Corda. Effects of antidepressants on the performance in the forced swim test of two psychogenetically selected lines of rats that differ in coping strategies to aversive conditions. Psychopharmacology, 211: 403-414, 2010.

F. Sanna, M.G. Corda, M.R. Melis, M.A. Piludu, S. Löber, H. Hübner, P. Gmeiner, A. Argiolas, O. Giorgi. Dopamine agonist-induced penile erection and yawning: a comparative study in outbred Roman high- and low-avoidance rats. Pharmacol Biochem Behav., 109: 59-66, 2013. doi: 10.1016/j.pbb.2013.05.002.

G. Piras, M.A. Piludu, O. Giorgi, M.G. Corda. Effects of chronic antidepressant treatments in a putative genetic model of vulnerability (Roman low-avoidance rats) and resistance (Roman high-avoidance rats) to stress-induced depression. Psychopharmacology (Berl), 231: 43-53, 2014. doi: 10.1007/s00213-013-3205-7.

F. Sanna, M.G. Corda, M.R. Melis, M.A. Piludu, O. Giorgi, A. Argiolas. Male Roman high- and low-avoidance rats show different patterns of copulatory behaviour: comparison with Sprague Dawley rats. Physiol Behav., 127: 27-36, 2014. doi: 10.1016/j.physbeh.2014.01.002.

F. Sanna, M.A. Piludu, M.G. Corda, A. Argiolas, O. Giorgi, M.R. Melis. Dopamine is involved in the different patterns of copulatory behaviour of Roman high and low avoidance rats: Studies with apomorphine and haloperidol. Pharmacol Biochem Behav, 124: 211-219, 2014. doi: 10.1016/j.pbb.2014.06.012.

M.G. Corda, G. Piras, M.A. Piludu, O. Giorgi. Differential effects of voluntary ethanol consumption on dopamine output in the nucleus accumbens shell of Roman high- and low-avoidance rats: A behavioral and brain microdialysis study. World Journal of Neuroscience (WJNS), 4: 279-292, 2014.

O. Giorgi, M.G.Corda, M. Sabariego, V. Giugliano, M.A. Piludu, M. Rosas, E. Acquas. Differential effects of cocaine on extracellular signal-regulated kinase phosphorylation in nuclei of the extended amygdala and prefrontal cortex of psychogenetically selected Roman high- and low-avoidance rats. J Neurosci Res, 93: 714-721, 2015. doi: 10.1002/jnr.23526. Epub 2014 Dec 11. PubMed PMID: 25502299.

F. Sanna, M.A. Piludu, M.G. Corda, M.R. Melis, O. Giorgi, A. Argiolas. Involvement of dopamine in the differences in sexual behaviour between Roman high- and low-avoidance rats: an intracerebral microdialysis study. Behav Brain Res, 281:177-186, 2015. doi: 10.1016/j.bbr.2014.12.009. Epub 2014 Dec 10. PubMed PMID: 25497705.

I. Oliveras, C. Del Río Alamos, T. Cañete, G. Blázquez, E. Martínez-Membrives, O. Giorgi, M. G. Corda, A. Tobeña, A. Fernández-Teruel. Pre-pulse inhibition predicts spatial working memory performance in the inbred Roman high- and low-avoidance rats and in genetically heterogeneous NIH-HS rats: relevance for studying pre-attentive and cognitive anomalies in schizophrenia. Front Behav Neurosci, 9: 213-229, 2015. doi: 10.3389/fnbeh.2015.00213.

N. Morello, O. Plicato, M. A. Piludu, L. Poddighe, M.P.Serra, M. Quartu, M.G. Corda, O. Giorgi, M. Giustetto. Effects of Forced Swimming Stress on ERK and Histone H3 Phosphorylation in Limbic Areas of Roman High- and Low-Avoidance Rats. PLoS One, 12: e0170093, 2017. doi: 10.1371/journal.pone.0170093.

I. Oliveras, A. Sánchez-González, D. Sampedro-Viana, M.A.Piludu, C. Río-Alamos, O. Giorgi, M.G. Corda, A. Aznar, J. González-Maeso, C. Gerbolés, G. Blázquez, T. Cañete, A. Tobeña, A. Fernández-Teruel. Differential effects of antipsychotic and propsychotic drugs on prepulse inhibition and locomotor activity in Roman high-(RHA) and low-avoidance (RLA) rats. Psychopharmacology (Berl), 234: 957-975, 2017. doi: 10.1007/s00213-017-4534-8.

F. Sanna, J. Bratzu, M.A. Piludu, M.G. Corda, M.R. Melis, O. Giorgi, A. Argiolas. Dopamine, Noradrenaline and Differences in Sexual Behavior between Roman High and Low Avoidance Male Rats: A Microdialysis Study in the Medial Prefrontal Cortex. Front. Behav. Neurosci. 11: 108, 2017. doi: 10.3389/fnbeh.2017.00108

M.A. Piludu, F. Sanna, A. Fernández Teruel, M. G. Corda, O. Giorgi. Differential sensitivity to shock-induced suppression of drinking in the Roman lines and strains of rats. Anticonflict effect of diazepam and proconflict effect of pentylenetetrazole. Eur. Neuropsychopharmacol. (2017). Under revision.