Occupational field

2021 – at present Associate Professor at the Dept. of Life and Environmental Sciences of the University of Cagliari, Italy

2013 – 2021  Technician at the Dept. of Life and Environmental Sciences of the University of Cagliari, Italy

2009 – 2013 Post-Doctoral fellowship in Pharmaceutical Technology at the Department of Life and Environmental Sciences, University of Cagliari, Italy

2008 Euro-PhD in Advanced Drug Delivery, at the University of Patras, Greece (2008)

2002 – 2007 PhD in Pharmaceutical Technology at the University of Cagliari, Italy

2001 Master’s degree in Pharmacy at the University of Cagliari, Italy

 

Teaching

Tutoring for the practical sessions of Pharmaceutical Technology class in the Master’sDegree in Pharmacy, University of Cagliari, Italy (2000-2008);

Teaching assistant (2002 to present);

Tutor to undergraduate and graduate students for research activity and master’s thesis in Pharmacy (2001 to present)

Intimate hygiene: general concepts and cosmetic aspects in post-graduate master in Cosmetic Industry at the University of Valencia, Spain.

Teaching for the practical sessions of Pharmaceutical Technology in the Master’s Degree in Pharmacy, at the University of Cagliari, Italy (2021 to present);

Teaching of Biopharmaceutics and formulation of biotechnological drugs in the Master’s Degree in Pharmaceutical Biotechnology, at the University of Cagliari, Italy (2021 to present);

DIDPRIN_ORIENT – PNRR-CDA 21/12/2022-Orientamento attivo Scuola-Università AA 22/23

 

Research topics

Formulation and characterization of innovative carriers based on phospholipid and/or polymer for the delivery of synthetic and natural drug;

Use of innovative vesicular systems for pulmonary administration of different drugs (natural or synthetic);

Combination of polymer and phospholipid vesicles for intestinal delivery;

Formulation of liposome-like system as carrier for the delivery of different active substances (natural or synthetic) to the skin.

In vitro/in vivo tests of nanosized Drug Delivery Systems

Scientific Sector:  Pharmaceutical Technology (03D2-CHIM09)

Research Projects

-   PRIN 2008”: Prot. 2008HTJLN2_002: "Idrogeli per il miglioramento della biodisponibilità di farmaci e molecole bioattive", component (2008-10);

-   Azioni Integrate Italia-Spagna 2009 in collaboration with the University of Valencia: “Proprietà chimico-fisiche di nanosistemi e loro applicazioni in campo farmaceutico”, component (2009-12);

-   PSR 2007-2013 Misura 124: Det. N. 4231/14 27/08/2014, “NANOUVATEC: Nanoincorporazione di Antiossidanti Naturali Ottenuti da Uva e Vite Autoctone per il Trattamento Eudermico del Corpo”, component (2014-15);

-   PSR 2007-2013 Misura 124: Det. N. 4230/14 27/08/2014, “NANOFITOCARE: Nanobiovescicole di Attivi Naturali per l'Ottenimento di Fitocomplessi Innovativi per il Trattamento dell'Omeostasi Corporea e l'Attiva Rigenerazione Epiteliale”, component (2014-15);

-   Fondazione Banco di Sardegna 2016: “Citrus lemon and Thymus herba-barona: from basic research to oral mouthwash and agrifood application” component (2016);

-   POR FESR Sardegna 2014–2020 Asse 1, Azione 1.1.3, Strategia 2, Programma di intervento 3, Competitività delle imprese: “NANOFITORADIODERM: Identificazione e caratterizzazione di fitocomplessi attivi da specie vegetali autoctone della Sardegna di interesse biomedicale veicolate mediante approcci formulativi innovativi in prodotti per il trattamento topico di radiodermiti e lesioni cutanee ulcerose”, component (2017-19);

-   POR FESR Sardegna 2014–2020 Asse 1, Azione 1.1.3, Strategia 2, Programma di intervento 3, Competitività delle imprese: “NUTRIFORMNANO”, component (2017-19);

-   Fundacio la Marato de TV3, European cooperation - Coated liposome nanocomplexes as drug delivery systems for treatment of leishmaniasis. component (2019-22);

-   Fondo di Sviluppo e Coesione 2014-2020. Patto per lo sviluppo della Regione Sardegna, Area Tematica 3, Linea d’Azione 3.1, Determinazione n. 8718 rep 842 del 30.11.2018, Nanodelivery technology for improved treatment of dermatological disorders, component (2019-21);

-   ENI CBC MED – Call for Standard Projects, A_A.2.1_0035- New Business opportunities & Environmental suSTainability using MED GRAPE nanotechnological products, BESTMEDGRAPE, Member of the Stearing Commetee (2019-22);

-   ENI CBC MED – Call for Standard Projects, A_A.2.1_0035- New Business opportunities & Environmental suSTainability using MED GRAPE nanotechnological products, BESTMEDGRAPE, Scientific Coordinator (2021-23);

-   Project founded by the Natural Resources Institute of Finland. Thematic area: Circular economy. Added value from side streams and Profitable and responsible primary production, Added value from new and underutilized raw materials. Application of novel and hybrid processing methods for the technological valorisation of agro-industrial side streams, POWER-EXTRACT, Principal Investigator of the Italian group, 2020-22.

-   MEDLENTISK: Partnership for an exchange of best practices on mastic tree fixed oil, an emblematic non-timber forest product in the Mediterranean, founded by Erasmus+ of European Union, component (2020-22).

-   Enonanoderm: Sviluppo di nuovi formulati topici destinati al mantenimento e/o ripristino del benessere cutaneo, attraverso l’attualizzazione tecnologico-formulativa di fitocomplessi derivati da diverse specie di “Vitis” estrati da vinacce derivanti dall’industria enologica, founded by Misura 16.2 PSR 2014-20, component (2022-24).

-   “Valorisation of agri-food side-streams to manufacture sustainable medical devices, nutraceutical and cosmeceutical products, feeds and fertilizers boosting health and quality of life - Waste2Health. Progetti biennali d’Ateneo FdS, Principal Investigator (2022-2024)

-   “Combinazione di bioattivi naturali e nanotecnologie per prevenire e contenere il contagio da COVID-19 – TECNOCOVID. RAS, L.R. 19/96 - Invito 2021., Annualità 2021, Principal Investigator (2022-2023)

-   Progetto PNRR – CN-National Center for Gene Therapy and Drugs based on RNA Technology (Codice MUR CN-00000041), component (2022-25).

-   DIDPRIN_ORIENT – PNRR-CDA 21/12/2022-Orientamento attivo Scuola-Università AA 22/23

-  POS H2b – POS MODELLI CELLULARI E COMPUTAZIONALI, MICRO E NANOTECNOLOGIE PER LA PERSONALIZZAZIONE DI TERAPIE INNOVATIVE, component

 

Research experience abroad

-   Visiting Researcher (1 month per year) at the Department of Pharmaceutical Technology and Parasitology of the University of Valencia (Spain).

-   Visiting Researcher, at the University of Valencia (Spain), Dept. of Pharmaceutical Technology, broadening her expertise in pre-clinical research involving animal testing (2011 to present);

-   ERASMUS + / KA1 UNICAFORSTAFF scholarship winner "Learning of new experimental protocols for in vitro and in vivo studies" University of Valencia, Spain (2016);

-   ERASMUS + / KA1 UNICAFORSTAFF scholarship winner "Learning of new approaches for the preparation of innovative vesicular systems" University of Patras, (Greece 2018);

-   ERASMUS+ Higher Education Staff Mobility (A.A. 2018/2019): practical sessions of Pharmaceutical Technology for students, PhD students and Staff aiming at promoting the internazionalization of the University of Cagliari. Activity performed at the University of Teheran (Iran).

 

Editorial and organizational assignments

 

Member of the organizing committee of the workshop "Vite e uva tra passato, presente e futuro", Oliena, Italy, 06.12.2014.

Member of the organizing committee of the workshop "Tecnologie innovative per la valorizzazione della flora autoctona della Sardegna nel settore biomedicale", Parco Tecnologico e Scientifico della Sardegna, Pula, Italy, 18.09.2015.

President of the organizing committee of the Second joint learning event MEDLENTISK, Parco Tecnologico e Scientifico della Sardegna, Pula, Italy, 16.11.2021.

2019-2021 Guest Editor for the Special Issue “Nanocarriers and Targeted Drug Delivery”, Nanomaterials (ISSN 2079-4991; Impact Factor: 4.034).

From 2020 to present Member of the Editorial board for the Journal Nanomaterials (ISSN 2079-4991; Impact Factor: 4.034).

From 2020 to present Member of the Editorial board for the Journal Antioxidants (ISSN 2076-3921; Impact Factor: 5.014).

From 2020 to present Editor for the Journal Current Cosmetic Science (ISSN: 2666-7800, Online; ISSN: 2666-7797, Print)

Topic Editor for the topic Oxidative Stress and Inflammation for the Journals Antioxidants (ISSN 2076-3921; Impact Factor: 6.312); Bopmedicines (ISSN: 2227-9059, Impact Factor: 6.081); International Journal of Molecular Sciences (ISSN: 1422-0067, Impact Factor: 5.024); Life (ISSN: 2075-1729, Impact Factor: 3.817).

Scientific Output

114 peer-reviewed papers, 4 European patents/patent applications, co-supervisor of 4 PhD students and 40 undergraduate students, 40 h index (Scopus), 3381 citations (Scopus).

1.          Manca M.L., Zaru M., Ennas G., Valenti D., Sinico C., Loy G., Fadda A.M.

Diclofenac-β-cyclodextrin binary systems: physicochemical characterization and in vitro dissolution and diffusion studies

AAPS PharmSciTech, 60, E58, 464-472, 2005.

2.          Lai F., Loy G., Manconi M., Manca M.L., Fadda A.M.

Artemisia arborescens essential oil loaded beads: preparation and characterization

AAPS PharmSciTech, 8, E67, E1-E7, 2007.

3.          Manca M.L., Mourtas S., Drakopoulos V., Fadda A.M., Antimisiaris S.G.

PLGA, chitosan or chitosan-coated PLGA microparticles for alveolar delivery? A comparative study of particle stability during nebulization

Colloids and Surfaces B: Biointerfaces, 62, 220-231, 2008.

4.          Lai F., Sinico C., Valenti D., Manca M.L., Fadda A.M.

Nanoemulsions as vehicle for topical 8-methoxypsoralen delivery

Journal of Biomedical Nanotechnology, 4, 1–5, 2008.

5.          Manca M.L., Loy G., Zaru M., Fadda A.M., Antimisiaris S.G.

Release of rifampicin from chitosan, PLGA and chitosan-coated PLGA microparticles

Colloids and Surfaces B: Biointerfaces. 67, 166-70, 2008.

6.          Zaru M., Manca M.L., Fadda A.M., Antimisiaris S.G.

Chitosan-coated liposomes for delivery to lungs by nebulization

Colloids and Surfaces B: Biointerfaces. 71, 88-95, 2009.

7.          Zaru M., Sinico C., De Logu A., Caddeo C., Lai F., Manca M.L., Fadda A.M.

Rifampicin-loaded liposomes for the passive targeting to alveolar macrophages: in vitro and in vivo evaluation

Journal of Liposome Research, 19, 68-76, 2009.

8.          Manconi M., Mura S., Manca M.L., Fadda A.M., Dolz M., Hernandez M.J., Casanovas A., Díez-Sales O.

Chitosomes as drug delivery systems for c-phycocyanin: preparation and characterization

International Journal of Pharmaceutics, 392, 92–100, 2010.

9.          Mura C., Manconi M., Valenti D., Manca M.L., Díez-Sales O., Loy G., Fadda, A.M.

In vitro study of N-succinyl chitosan for targeted delivery of 5-aminosalicylic acid to colon

Carbohydrate Polymers, 85, 578-583, 2011.

10.      Lai F., Pini E., Angioni G., Manca M.L., Perricci J., Sinico C. and Fadda A.M.

Nanocrystals as tool to improve piroxicam dissolution rate in novel orally disintegrating tablets

European Journal of Pharmaceutics and Biopharmaceutics, 79, 552-558, 2011.

11.      Manca M.L., Manconi M., Valenti D., Lai F., Loy G., Matricardi P., Fadda A.M.

Liposomes coated with chitosan/xanthan gum (chitosomes) as potential carriers for pulmonary delivery of rifampicin

Journal of Pharmaceutical Sciences, 101, 566-75, 2012.

12.      Manca M.L., Sinico C., Maccioni A.M., Diez-Sales O., Fadda A.M., Manconi M.

Composition influence on pulmonary delivery of rifampicin liposomes

Pharmaceutics, 4, 590-606, 2012.

13.      Carboni M., Falchi A.M., Lampis S., Sinico C., Manca M.L., Schmidt J., Talmon Y., Murgia S., Monduzzi M.

Physicochemical, Cytotoxic, and Dermal Release Features of a Novel Cationic Liposome Nanocarrier

Advanced Healthcare Materials, 2, 692-701, 2013.

14.      Manconi M., Nácher A., Merino V., Merino-Sanjuan M., Manca M.L., Mura C., Mura S., Fadda A.M., Diez-Sales O.

Improving oral bioavailability and pharmacokinetics of liposomal metformin by glycerolphosphate-chitosan microcomplexation

AAPS PharmSciTech, 14, 485-496, 2013.

15.      Manca M.L., Cassano R., Valenti D., Trombino S., Ferrarelli T., Picci N., Fadda A.M., Manconi M.

Isoniazid-gelatin conjugate microparticles containing rifampicin for the treatment of tuberculosis

Journal of Pharmacy and Pharmacology, 65, 1302-1311, 2013.

16.      Manca M.L., Manconi M., Falchi A.M., Castangia I., Valenti D., Lampis S., Fadda A.M.

Close-packed vesicles for diclofenac skin delivery and fibroblast targeting

Colloids and Surfaces B: Biointerfaces, 111, 609-617, 2013.

17.      Manca M.L., Zaru M., Manconi M., Lai F., Valenti D., Sinico C., Fadda A.M.

Glycerosomes: a new tool for effective dermal and transdermal drug delivery

International Journal of Pharmaceutics, 455, 66–74, 2013.

18.      Castangia I., Manca M.L., Matricardi P., Sinico C., Lampis S., Fernàndez-Busquets X., Fadda A.M., Manconi M.

Effect of diclofenac and glycol intercalation on structural assembly of phospholipid lamellar vesicles

International Journal of Pharmaceutics, 456, 1–9, 2013.

19.      Manca M.L., Castangia I., Matricardi P., Lampis S., Fernàndez-Busquets X.d, Fadda, A.M., Manconi, M.

Molecular arrangements and interconnected bilayer formation induced by alcohol or polyalcohol in phospholipid vesicles

Colloids and Surfaces B: Biointerfaces 117, 360-367, 2014.

20.      Manca M.L., Valenti D., Sales O.D., Nacher A., Fadda A.M., Manconi M.

Fabrication of polyelectrolyte multilayered vesicles as inhalable dry powder for lung administration of rifampicin

International Journal of Pharmaceutics, 472, 102-109, 2014.

21.      Manca M.L.*, Castangia I., Caddeo C., Pando D., Escribano E., Valenti D., Lampis S., Zaru M., Fadda A.M., Manconi M.

Improvement of quercetin protective effect against oxidative stress skin damages by incorporation in nanovesicles

Colloids and Surfaces B: Biointerfaces 123, 566-574, 2014.

22.      Manca M.L., Manconi M., Nacher A., Carbone C., Valenti D., Maccioni A.M., Sinico C., Fadda A.M.

Development of novel diolein-niosomes for cutaneous delivery of tretinoin: Influence of formulation and in vitro assessment

International Journal of Pharmaceutics, 477, 176-186, 2014.

23.      Moulaoui K., Caddeo C., Manca M.L., Castangia I., Valenti D., Escribano E., Atmani D., Fadda A.M., Manconi M.

Identification and nanoentrapment of polyphenolic phytocomplex from Fraxinus angustifolia: In vitro and in vivo wound healing potential

European Journal of Medicinal Chemistry, 89, 179-188, 2015.

24.      Manca M.L., Zaru M., Bacchetta G., Biggio T., Cappai N., Cabras A., Falchi A.M., Manconi M., Fadda A.M.

A new technological approach to improve the efficacy of a traditional herbal medicinal product in wound healing

Industrial Crops and Products 63, 71–78, 2015.

25.      Castangia I., Manca M.L., Matricardi P., Nácher A., Fernàndez Busquets X., Fadda A.M., Manconi M.

Effects of ethanol and diclofenac on the organization of hydrogenated phosphatidylcholine bilayer vesicles and their ability as skin carriers

Journal of Material Science Material in Medicine, 26, 137, 2015.

26.      Castangia I., Manca M.L., Caddeo C., Maxia A., Murgia S., Pons R., Demurtas D., Pando D., Falconieri D., Peris J.E., Fadda A.M., Manconi M.

Faceted phospholipid vesicles tailored for the delivery of Santolinainsularis essential oil to the skin

Colloids and Surface B: Biointerfaces 132, 185–193, 2015.

27.      Castangia I., Caddeo C., Manca M.L.*, Casu L., Catalan Latorre A., Díez-Sales O., Ruiz-Saurí A., Bacchetta G., Fadda A.M., Manconi M.

Delivery of liquorice extract by liposomes and hyalurosomes toprotect the skin against oxidative stress injuries

Carbohydrate Polymers, 134, 657-663, 2015.

28.      Manca M.L., Castangia I., Zaru M., Nacher A., Valenti D., Fernandez-Busquets X., Fadda A.M., Manconi M.

Development of curcumin loaded sodium hyaluronate immobilized vesicles (hyalurosomes) and their potential on skin inflammation and wound restoring

Biomaterials, 71, 100-109, 2015.

29.      Manca M.L., Peris J.E., Melis V., Valenti D., Cardia M.C., Lattuada D., Escribano Ferrer E., Fadda A.M., Manconi M.

Nanoincorporation of Curcumin in Polymer-Glycerosomes and Evaluation of their In Vitro-In Vivo Suitability as Pulmonary Delivery Systems

RSC Advances, 5, 105149-105159, 2015.

30.      Manca M.L., Marongiu F., Castangia I., Catalán-Latorre A., Caddeo C., Bacchetta G., Ennas G., Zaru M., Fadda A.M., Manconi M.

Protective effect of grape extract phospholipid vesicles against oxidative stress skin damages

Industrial Crops and Products, 83, 561-567, 2016.

31.      Castangia I, Manca M.L.*, Catalán-Latorre A, Maccioni AM, Fadda AM, Manconi M.

Phycocyanin-encapsulating hyalurosomes as carrier for skin delivery and protection from oxidative stress damage

Journal of Material Science Material in Medicine 27, 1-10, 2016.

32.      Melis V., Manca M.L.*, Bullita E., Tamburini E., Castangia I., Cardia M.C., Valenti D., Fadda A.M., Peris J.E, Manconi M.

Inhalable polymer-glycerosomes as safe and effective carriers for rifampicin delivery to the lungs

Colloids and Surface B: Biointerfaces 143, 301–308, 2016.

33.      Manca M.L., Matricardi P., Cencetti C., Peris J.E., Melis V., Carbone C., Escribano E., Zaru M., Fadda A.M., Manconi M.

Combination of argan oil and phospholipids for the development of an effective liposome-like formulation able to improve skin hydration and allantoin dermal delivery

International Journal of Pharmaceutics, 505, 204-211, 2016.

34.      Castangia I., Manca M.L.*, Caddeo C., Bacchetta G., Pons R., Demurtas D., Diez-Sales O., Fadda, A.M., Manconi M.

Santosomes as natural and efficient carriers for the improvement of phycocyanin reepithelising ability in vitro and in vivo

European Journal of Pharmaceutics and Biopharmaceutics, 103, 149-158, 2016.

35.      Manconi M., Manca M.L.*, Marongiu F., Caddeo C., Castangia I., Petretto G.L., Pintore G., Sarais G., D'hallewin G., Zaru M., Bacchetta G., Fadda A.M.

Chemical characterization of Citrus limon var. pompia and incorporation in phospholipid vesicles for skin delivery

International Journal of Pharmaceutics, 506, 449-457, 2016.

36.      Catalan-Latorre A., Ravaghi M., Manca M.L.*, Caddeo C., Marongiu F., Ennas G., Escribano-Ferrer E., Peris J.E., Diez-Sales O., Fadda A.M., Manconi M

Freeze-dried eudragit-hyaluronan multicompartment liposomes to improve the intestinal bioavailability of curcumin

European Journal of Pharmaceutics and Biopharmaceutics, 107, 49-55, 2016.

37.      Mir-Palomo S., Nácher A., Díez-Sales O., Ofelia Vila Busó M.A., Caddeo C., Manca M.L., Manconi M., Fadda A.M., Saurí A.R

Inhibition of skin inflammation by baicalin ultradeformable vesicles

International Journal of Pharmaceutics, 511, 23-29, 2016.

38.      Manca M.L., Cencetti C., Matricardi P., Castangia I., Zaru M., Diez Sales O., Nacher A., Valenti D., Maccioni A.M., Fadda A.M., Manconi M.

Glycerosomes: use of hydrogenated soy phosphatidylcholine mixture and its effect on vesicle features and diclofenac skin penetration

International Journal of Pharmaceutics, 511, 198-204, 2016.

39.      Manconi M., Marongiu F., Castangia I., Manca M.L., Caddeo C., Tuberoso C.I.G., D’hallewin G., Bacchetta G., Fadda A.M.

Polymer-associated liposomes for the oral delivery of grape pomace extract

Colloids and Surface B: Biointerfaces, 146, 910-917, 2016.

40.      Castangia I, Marongiu F., Manca M.L., Pompei R., Angius F., Ardu A., Fadda A.M., Manconi M., Ennas G.

Combination of grape extract-silver nanoparticles and liposomes: A totally green approach

European Journal of Pharmaceutical Sciences, 97, 62-69, 2017.

41.      Caddeo C., Manca M.L.*, Matos M., Gutierrez G., Díez-Sales O., Peris J.E., Usach I., Fernàndez Busquets X., Fadda, A.M.

Functional response of novel bioprotective poloxamer-structured vesicles on inflamed skin

Nanomedicine: Nanotechnology, Biology, and Medicine, 13, 1127-1136, 2017.

42.      Vitonyte J., Manca M.L., Caddeo C., Valenti D., Peris J.E., Usach I., Nacher A., Matos M., Gutiérrez G., Orrù G., Fernàndez-Busquets X., Fadda A.M., Manconi M.

Bifunctional viscous nanovesicles co-loaded with resveratrol and gallic acid for skin protection against microbial and oxidative injuries

European Journal of Pharmaceutics and Biopharmaceutics, 114, 278-287, 2017.

43.      Manconi M., Marongiu F., Manca M.L., Caddeo C., Sarais G., Cencetti C., Pucci L., Longo, V., Bacchetta G., Fadda A.M.

Nanoincorporation of bioactive compounds from red grape pomaces: In vitro and ex vivo evaluation of antioxidant activity

International Journal of Pharmaceutics, 523, 159-166, 2017.

44.      Manconi M., Manca M.L.*, Valenti D., Escribano E., Hillaireau H., Fadda A.M., Fattal E.

Chitosan and hyaluronan coated liposomes for pulmonary administration of curcumin

International Journal of Pharmaceutics, 525, 203-210, 2017.

45.      Zoratto N., Palmieri F.R., Cencetti C., Montanari E., Di Meo C., Manca M.L., Manconi M., Matricardi P.

Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications

Gels, 3, 18, 2017.

46.      Amore E., Ferraro M., Manca M.L., Gjomarkaj M., Giammona G., Pace E., Bondì M.L.

Mucoadhesive solid lipid microparticles for controlled release of a corticosteroid in the chronic obstructive pulmonary disease treatment

Nanomedicine, 12, 2287-2302, 2017.

47.      Manca M.L., Manconi M., Zaru M., Valenti D., Peris J.E., Matricardi P., Maccioni A.M., Fadda A.M.

Glycerosomes: Investigation of role of 1,2-dimyristoyl-sn-glycero-3-phosphatidycholine (DMPC) on the assembling and skin delivery performances

International Journal of Pharmaceutics, 532, 401-407, 2017.

48.      Manconi M., Manca M.L.*, Caddeo C., Valenti D., Cencetti C., Diez-Sales O., Nacher A, Mir-Palomo S., Terencio M.C., Demurtas D., Gomez-Fernandez J.C., Aranda F.J., Fadda A.M., Matricardi P.

Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin

Nanomedicine: Nanotechnology, Biology, and Medicine, 14, 569-579, 2018.

49.      Catalán-Latorre A., Pleguezuelos-Villa M., Castangia I., Manca M.L.*, Caddeo C., Nácher A., Díez-Sales O., Peris J.E., Pons R., Escribano-Ferrer E., Fadda A.M., Manconi M.

Nutriosomes: prebiotic delivery systems combining phospholipid, soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation

Nanoscale, 10, 1957-1969, 2018.

50.      Manconi M., Manca M.L.*, Caddeo C., Cencetti C., di Meo C., Zoratto N., Nacher A., Fadda A.M., Matricardi P.

Preparation of gellan-cholesterol nanohydrogels embedding baicalin and evaluation of their wound healing activity

European Journal of Pharmaceutics and Biopharmaceutics, 127, 244-249, 2018.

51.      Coma-Cros E.M., Biosca A., Lantero E., Manca M.L., Caddeo C., Gutiérrez L., Ramírez, M., Borgheti-Cardoso L.N., Manconi M., Fernàndez-Busquets X.

Antimalarial activity of orally administered curcumin incorporated in eudragit®-containing liposomes

International Journal of Molecular Sciences, 19, 1361, 2018.

52.      Manconi M., Petretto G., D'hallewin G., Escribano E., Milia E., Pinna R., Palmieri A., Firoznezhad M., Peris J.E., Usach I., Fadda A.M., Caddeo C., Manca M.L.

Thymus essential oil extraction, characterization and incorporation in phospholipid vesicles for the antioxidant/antibacterial treatment of oral cavity diseases

Colloids and Surfaces B: Biointerfaces, 171, 115-122, 2018.

53.      Caddeo C., Manca M.L.?, Peris J.E., Usach I., Diez-Sales O., Matos M., Fernàndez-Busquets X., Fadda A.M., Manconi M.

Tocopherol-loaded transfersomes: In vitro antioxidant activity and efficacy in skin regeneration

International Journal of Pharmaceutics, 551, 34-41, 2018.

54.      Scano A., Ebau F., Manca M.L., Cabras V., Marincola F.C., Manconi M., Pilloni M., Fadda A.M., Ennas G.

Novel drug delivery systems for natural extracts: The case study of Vitis Vinifera extract-SiO2 nanocomposites

International Journal of Pharmaceutics, 551, 84-96, 2018.

55.      Manconi M., Manca M.L., Caddeo C., Sarais G., Palmieri A., D’Hallewin G., Fadda A.M.

Citrus limon Extract Loaded in Vesicular Systems for the Protection of Oral Cavity Medicines, 5, 0108, 2018.

56.      Brotzu G., Fadda A.M., Manca M.L., Manca T., Marongiu F., Campisi M., Consolaro F.

A liposome-based formulation containing equol, dihomo-γ-linolenic acid (DGLA), and propionyl-L-carnitine to prevent and treat hair loss: a prospective investigation

Dermatologic Therapy, e12778, 1-7, 2018.

57.      Manca M.L., Mir-Palomo S., Caddeo C., Nacher A., Díez-Sales O., Peris J-E., Pedraz J.L., Fadda A.M., Manconi M.

Sorbitol-penetration enhancer containing vesicles loaded with baicalin for the protection and regeneration of skin injured by oxidative stress and UV radiation

International Journal of Pharmaceutics, 555, 175-183, 2019.

58.      Manca M.L., Firoznezhad M., Caddeo C., Marongiu F., Escribano-Ferrer E., Sarais G., Peris J.E., Usach I., Zaru M., Manconi M., Fadda A.M.

Phytocomplexes extracted from grape seeds and stalks delivered in phospholipid vesicles tailored for the treatment of skin damages

Industrial Crops and Products, 128, 471-478, 2019.

59.      Manconi M., Manca M.L.*, Escribano-Ferrer E., Coma-Cros E.M., Biosca A., Lantero E., Fernàndez-Busquets X., Fadda A.M., Caddeo C.

Nanoformulation of curcumin loaded eudragit-nutriosomes to counteract malaria infection by a dual strategy: improving antioxidant intestinal activity and systemic efficacy

International Journal of Pharmaceutics, 556, 82-88, 2019.

60.      Mir-Palomo S., Nácher A., Vila Busó M.A.O, Caddeo C., Manca M.L., Manconi M., Díez-Sales O.

Baicalin and berberine ultradeformable vesicles as potential adjuvant in vitiligo therapy

Colloids and Surfaces B: Biointerfaces, 175, 654-662, 2019.

61.      Rezvani M., Manca M.L.*, Caddeo C., Escribano-Ferrer E., Carbone C., Peris J.E., Usach I., Diez-Sales O., Fadda A.M., Manconi M.

Co-Loading of Ascorbic Acid and Tocopherol in Eudragit-Nutriosomes to Counteract Intestinal Oxidative Stress

Pharmaceutics, 11, 13, 2019.

62.      Manca M.L.*, Lattuada D., Valenti D., Marelli O., Corradini C., Fernàndez-Busquets X., Zaru M., Maccioni A.M., Fadda A.M., Manconi M.

Potential therapeutic effect of curcumin loaded hyalurosomes against inflammatory and oxidative processes involved in the pathogenesis of rheumatoid arthritis: The use of fibroblast-like synovial cells cultured in synovial fluid

European Journal of Pharmaceutics and Biopharmaceutics, 136, 84-92, 2019.

63.      Amore E., Manca M.L., Ferraro M., Valenti D., La Parola V., Di Vincenzo S., Gjomarkaj M., Giammona G., Bondì M.L., Pace E.

Salmeterol Xinafoate (SX) Loaded Into Mucoadhesive Solid Lipid Microparticles for COPD Treatment

International Journal of Pharmaceutics, 562, 351-358, 2019.

64.      Pinna R., Filigheddu E., Juliano C., Palmieri A., Manconi M., D’hallewin G., Petretto G., Maioli M., Caddeo C., Manca M.L., Solinas G., Bortone A., Campanella V., Milia E.

Antimicrobial Effect of Thymus capitatus and Citrus limon var. pompia as Raw Extracts

and Nanovesicles

Pharmaceutics, 11, 234, 1-19, 2019.

65.      Manca M.L.*, Usach I., Peris J.E., Ibba A., Orrù G., Valenti D., Escribano-Ferrer E., Gomez-Fernandez J.C., Aranda F.J., Fadda A.M., Manconi M.

Optimization of innovative three-dimensionally-structured hybrid vesicles to improve the cutaneous delivery of clotrimazole for the treatment of topical candidiasis

Pharmaceutics, 11, 263, 1-18, 2019.

66.      Grotz E., Tateosianf N.L., Salgueiro J., Bernabeu E., Gonzalez L., Manca M.L., Amiano N., Valenti D., Manconi M., García V., Moretton M., Chiappetta D.A.

Pulmonary delivery of rifampicin-loaded soluplus micelles against Mycobacterium tuberculosis

Journal of Drug Delivery Science and Technology, 53, 101170, 2019.

67.      Manconi M., Caddeo C., Nacher A., Diez-Sales O., Peris J.E., Escribano Ferrer E., Fadda A.M., Manca M.L.

Eco-scalable baicalin loaded vesicles developed by combining phospholipid with ethanol, glycerol, and propylene glycol to enhance skin permeation and protection

Colloids and Surfaces B: Biointerfaces, 184, 110504, 2019.

68.      Pleguezuelos-Villa M., Diez-Sales O., Manca M.L., Manconi M., Ruiz Sauri A., Escribano-Ferrer E., Nácher A.

Mangiferin glycethosomes as a new potential adjuvant for the treatment of psoriasis

International Journal of Pharmaceutics, 573, 118844, 2020.

69.      Manca M.L., Lai F., Pireddu R., Valenti D., Schlich M., Pini E., Ailuno G., Fadda A.M., Sinico C.

Impact of nanosizing on dermal delivery and antioxidant activity of quercetin nanocrystals

Journal of Drug Delivery Science and Technology, 55, 101482, 2020.

70.      Usach I., Margarucci E., Manca M.L., Caddeo C., Aroffu M., Petretto G.L., Manconi M., Peris J.E.

Comparison Between Citral and Pompia Essential Oil Loaded in Phospholipid Vesicles for the Treatment of Skin and Mucosal Infections

Nanomaterials, 10, 286, 2020.

71.      Leyva-Jiménez F. J., Manca M.L., Manconi M., Caddeo C., Vázquez J. A., Lozano-Sánchez J., Escribano-Ferrer E., Arráez-Román D., Segura-Carretero A.

Incorporation of Lippia citriodora Microwave Extract into Total-Green Biogelatin-Phospholipid Vesicles to Improve Its Antioxidant Activity

Nanomaterials, 10, 765, 2020.

72.      Lai F., Caddeo C., Manca M.L., Manconi M., Sinico C., Fadda A.M.

What's new in the field of phospholipid vesicular nanocarriers for skin drug delivery?

International Journal of Pharmaceutics, 583, 119398, 2020.

73.      Allaw M., Manca M.L.*, Caddeo C., Recio M.C., Pe?rez-Brocal V., Moya A., Ferna?ndez-Busquet X., Manconi M.

Advanced strategy to exploit wine-making waste by manufacturing T antioxidant and prebiotic fibre-enriched vesicles for intestinal health

Colloids and Surfaces B: Biointerfaces, 193, 111146, 2020.

74.      Allaw M., Pleguezuelos-Villa M., Manca M.L.*, Caddeo C., Aroffu M., Nacher A., Diez-Sales O., Ruiz Saur? ?A., Escribano Ferrer E., Fadda A.M., Manconi M.

Innovative strategies to treat skin wounds with mangiferin: fabrication of transfersomes modified with glycols and mucin

Nanomedicine (London, England), 15, 1671–1685, 2020.

75.      Mir-Palomo s., Nacher A., Vila-Busò O., Caddeo C., Manca M.L., Saurì A.R., Escribano-Ferrer E., Manconi M., Dìez-Sales O.

Co-loading of finasteride and baicalin in phospholipid vesicles tailored for the treatment of hair disorders

Nanoscale, 12, 16143-16152, 2020.

76.      Manconi M., Caddeo C., Manca M.L*, Fadda A.M.

Oral delivery of natural compounds by phospholipid vesicles

Nanomedicine (London, England), 15, 1795–1803, 2020.

77.      Manca M.L.*, Casula E., Marongiu F., Bacchetta G., Sarais G., Zaru M., Escribano Ferrer E., Peris J.E., Usach I., Fais S., Scano A., Orrù G., Maroun R.G., Fadda A.M., Manconi M.

From waste to health: sustainable exploitation of grape pomace seed extract to manufacture antioxidant, regenerative and prebiotic nanovesicles within circular economy

Scientific Reports, 10, 14184, 2020.

78.      Palmas L., Aroffu M., Petretto G., Escribano-Ferrer E., Diez-Sales O., Usach I., Peris J.E., Marongiu F., Ghavam M., Fais S., Orrù G., Abi Rached R., Manca M.L.*, Manconi M.

Entrapment of Citrus limon var. Pompia essential oil or pure citral in liposomes tailored as mouthwash for the treatment of oral cavity diseases

Pharmaceuticals, 13, 216, 2020.

79.      Ghavam M., Manca M.L., Manconi M., Bacchetta G.

Chemical composition and antimicrobial activity of essential oils obtained from leaves and flowers of Salvia hydrangea DC. ex Benth.

Scientific Reports, 10, 15647, 2020.

80.      Allaw M., Manconi M., Aroffu M., Marongiu F., Porceddu M., Bacchetta G., Usach I., Abi Rached R., Rajha H.N., Maroun R.G., Pedraz J.L., Lopez-Mendez T.B., Fadda A.M., Manca M.L.

Extraction, characterization and incorporation of Hypericum scruglii extract in ad hoc formulated phospholipid vesicles designed for the treatment of skin diseases connected with oxidative stress

Pharmaceutics, 12, 1010, 2020

81.      Leyva-Jiméneza F.J., Manca M.L., Manconi M., Caddeo C., Vázquez J.A., Carbone C., Lozano-Sáncheza J., Arráez-Romána D., Segura-Carretero A.

Development of advanced phospholipid vesicles loaded with Lippia citriodora pressurized liquid extract for the treatment of gastrointestinal disorders

Food Chemistry, 337, 127746, 2021.

82.      Ghavam M., Manconi M., Manca M.L., Bacchetta G.

Extraction of essential oil from Dracocephalum kotschyi Boiss. (Lamiaceae), identification of 2 two active compounds and evaluation of the antimicrobial properties

Journal of Ethnopharmacology, 267, 113513, 2021

83.      Manca M.L., Ferraro M., Pace E., Di Vincenzo S., Valenti D., Fernandez-Busquets X., Peptu C.A., Manconi

Loading of beclomethasone in liposomes and hyalurosomes improved with mucin as effective approach to counteract the oxidative stress generated by cigarette smoke extract

Nanomaterials, 11 (4), 850, 202

84.      Manca M.L., Manconi M., Meloni M.C., Marongiu F., Allaw M., Usach I., Peris J.E., Escribano-Ferrer E., Tuberoso C.I.G., Gutierrez G., Matos M., Ghavam M.

Nanotechnology for Natural Medicine: Formulation of Neem Oil Loaded Phospholipid Vesicles Modified with Argan Oil as a Strategy to Protect the Skin from Oxidative Stress and Promote Wound Healing.

Antioxidants, 10, 670, 2021

85.      Ghavam M., Afzali A., Manca M.L.

Chemotype of damask rose with oleic acid (9 octadecenoic acid) and its antimicrobial effectiveness.

Scientific Reports, 11(1), 8027, 2021

86.      Ghavam, M., Afzali, A., Manconi, M., Bacchetta G., Manca M.L.

Variability in chemical composition and antimicrobial activity of essential oil of Rosa damascena Herrm. from mountainous regions of Iran.

Chem. Biol. Technol. Agric. 8, 22, 2021

87.      Casula E., Manca M.L.*, Perra M., Pedraz J.L., Lopez-Mendez T.B., Lozano A., Calvo E., Zaru M., Manconi M.

Nasal Spray Formulations Based on Combined Hyalurosomes and Glycerosomes Loading Zingiber officinalis Extract as Green and Natural Strategy for the Treatment of Rhinitis and Rhinosinusitis.

Antioxidants, 10, 1109, 2021

88.      Perra M., Lozano-Sanchez J., Leyva-Jimenez F.J., Segura-Carretero A., Pedraz J.L., Bacchetta G., Muntoni A., De Gioannis G., Manca M.L.*, Manconi M.

Extraction of the antioxidant phytocomplex from wine-making by-products and sustainable loading in phospholipid vesicles specifically tailored for skin protection.

Biomedicine & Pharmacotherapy 142, 111959, 2021

89.      Quispe C., Cruz-Martins N., Manca M.L., Manconi M., Sytar O., Hudz N., Shanaida M., Kumar M., Taheri Y, Martorell M.,Sharifi-Rad J., Pintus G., Cho W.C.

Nanoderived Therapeutic Formulations with Curcumin in Inflammation-Related Diseases

Oxidative Medicine and Cellular Longevity 3149223, 2021

90.      Allaw M., Manca M.L.*, Gomez-Fernandez J.C., Pedraz J.L., Terencio M.C., Diez Sales O., Nacher A., Manconi M.

Oleuropein multicompartment nanovesicles enriched with collagen as a natural strategy for the treatment of skin wounds connected with oxidative stress

Nanomedicine (London, England), 10.2217/nnm-2021-0197, 2021

91.      Allaw M., Manconi M., Caboni P., Bacchetta G., Escribano-Ferrer E., Peris J.E., Nacher A., Diez-Sales O., Manca M.L.

Formulation of liposomes loading lentisk oil to ameliorate topical delivery, attenuate oxidative stress damage and improve cell migration in scratch assay

Biomedicine & Pharmacotherapy 144, 112351, 2021

92.      Casula E., Manca M.L.*, Manconi M.

An integrative review on the uses of plant-derived bioactives formulated in conventional and innovative dosage forms for the local treatment of damaged nasal cavity

International Journal of Pharmaceutics, 610, 121229, 2021.

93.      Casula E., Manconi M., Vázquez J.A., Belen Lopez-Mendez T., Pedraz J. L., Calvo E., Lozano A., Zaru M., Ascenso A., Manca M.L.

Design of a Nasal Spray Based on Cardiospermum halicacabum Extract Loaded in Phospholipid Vesicles Enriched with Gelatin or Chondroitin Sulfate

Molecules, 26, 6670, 2021.

94.      Castangia I., Manca M.L.*, Allaw M., Hellstrom J., Granato D., Manconi M.

Jabuticaba (Myrciaria jaboticaba) Peel as a Sustainable Source of Anthocyanins and Ellagitannins Delivered by Phospholipid Vesicles for Alleviating Oxidative Stress inHuman Keratinocytes

Molecules, 26, 6697, 2021.

95.      Hoss I., Rajha H. N., El Khoury R., Youssef S., Manca M.L., Manconi M., Louka N., Maroun R.

Valorization of Wine?Making By?Products’ Extracts in Cosmetics

Cosmetics 8, 109, 2021.

96.      Casula E., Manconi M., Belen Lopez-Mendez T., Pedraz J. L., Calvo E., Lozano A., Zaru M., Castangia I., Orrù G., Fais S., Manca M.L.

Complementary effect of Zingiber officinalis extract and citral in counteracting non allergic nasal congestion by simultaneous loading in ad hoc formulated phospholipid vesicles

Colloids and Surfaces B: Biointerfaces, 209, 112170, 2022.

97.      Gil K.A., Jerkovi I. , Marijanovi Z., Manca M.L., Caddeo C., Tuberoso C. I. G.

Evaluation of an innovative sheep cheese with antioxidant activity enriched with different thyme essential oil lecithin liposomes

LWT Food Science and Technology 154, 112808, 2022.

98.      Allaw M., Manca M.L.*, Castangia I., Manconi M.

From plants to phospholipid vesicles: A comprehensive review on the incorporation of phytochemicals into phospholipid vesicles designed for skin applications with special focus on scalability and in vitro and in vivo efficacy

Journal of Drug Delivery Science and Technology, 67, 103049, 2022

99.      Rezvani M., Manca M.L., Muntoni A., De Gioannis G., Pedraz J.L., Gutierrez G., Matos M., Fadda A.M., Manconi M.

From process effluents to intestinal health promotion: Developing biopolymer-whey liposomes loaded with gingerol to heal intestinal wounds and neutralize oxidative stress

International Journal of Pharmaceutics, 613, 121389, 2022.

100.   Castangia I., Manca M.L.*, Razavi S.H., Nácher A., Díez-Sales O., Peris J.E., Allaw M., Terencio M.C., Usach I., Manconi M.

Canthaxanthin Biofabrication, Loading in Green Phospholipid Vesicles and Evaluation of In Vitro Protection of Cells and Promotion of Their Monolayer Regeneration.

Biomedicines, 10, 157, 2022.

101.   Castangia I., Manconi M., Allaw M., Perra M., Orrù G., Fais S., Scano A., Escribano-Ferrer E., Ghavam M., Rezvani M., Manca M.L.

Mouthwash Formulation Co-Delivering Quercetin and Mint Oil in Liposomes Improved with Glycol and Ethanol and Tailored for Protecting and Tackling Oral Cavity.

Antioxidants, 11, 367, 2022.

102.   Firoznezhad M., Castangia I., Tuberoso C.I.G, Cottiglia F., Marongiu F., Porceddu M., Usach I., Escribano-Ferrer E., Manca M.L., Manconi M.

Formulation and In Vitro Efficacy Assessment of Teucrium marum Extract Loading Hyalurosomes Enriched with Tween 80 and Glycerol.

Nanomaterials, 12(7), 1096, 2022.

103.   Perra M., Fancello L., Castangia I., Allaw M., Escribano-Ferrer E., Peris J.E., Usach I., Manca M.L., Koycheva I.K., Georgiev M.I., Manconi M.

Formulation and Testing of Antioxidant and Protective Effect of Hyalurosomes Loading Extract Rich in Rosmarinic Acid Biotechnologically Produced from Lavandula angustifolia Miller.

Molecules, 27(8), 2423, 2022.

104.   Galdopórpora J.M, Martinena C., Bernabeu E., Riedel J., Palmas L., Castangia I., Manca M.L.*, Garcés M., Lázaro-Martinez J., Salgueiro M.J., Evelson P., Tateosian N.L., Chiappetta D.A, Moretton M.A.

Inhalable Mannosylated Rifampicin–Curcumin Co-Loaded Nanomicelles with Enhanced In Vitro Antimicrobial Efficacy for an Optimized Pulmonary Tuberculosis Therapy.

Pharmaceutics, 14(5), 959, 2022.

105.   Salem Y., Rajha H.N., Franjieh D., Hoss I., Manca M.L.*, Manconi M., Castangia I., Perra M., Maroun R.G., Louka N..

Stability and Antioxidant Activity of Hydro-Glyceric Extracts Obtained from Different Grape Seed Varieties Incorporated in Cosmetic Creams.

Anrioxidants, 11(7), 1348, 2022.

106.  Perra M., Manca M.L.*, Tuberoso C.I.G., Caddeo C., Marongiu F., Peris J.E., Orrù G., Ibba A., Fern`andez-Busquets X., Fattouch S., Bacchetta G., Manconi M.

A green and cost-effective approach for the efficient conversion of grape byproducts into innovative delivery systems tailored to ensure intestinal protection and gut microbiota fortification.

Innovative Food Science and Emerging Technologies, 80, 103103, 2022.

107.   Perra M., Cuena-Lombraña A., Bacchetta G., Manca M.L., Manconi M., Maroun R.G., Muntoni A., Tuberoso C.I.G, Gil K.A., De Gioannis G.

Combining Different Approaches for Grape Pomace Valorization: Polyphenols Extraction and Composting of the Exhausted Biomass.

Sustainability, 14, 10690, 2022.

108.   Perra M., Bacchetta G., Muntoni A., De Gioannis G., Castangia I., Rajha H.N., Manca M.L.*, Manconi M.

An outlook on modern and sustainable approaches to the management of grape pomace by integrating green processes, biotechnologies and advanced biomedical approaches.

Journal of Functional Foods, 98, 105276, 2022.

109.   Ghavam M., Bacchetta G., Castangia I., Manca M.L.

Evaluation of the composition and antimicrobial activities of essential oils from four species of Lamiaceae Martinov native to Iran.

Scientifc Reports, 12, 17044, 2022

110.  Salem Y., Hiba N. R., van den Broek L. A. M., Safi C., Togtema A., Manconi M., Manca M.L., Debs E., Hobaika Z., Maroun R. G., Louka N.

Multi-Step Biomass Fractionation of Grape Seeds from Pomace, a Zero-Waste Approach.

Plants, 11, 2831, 2022

111.  Ebau F., Scano A., Manca M.L., Manconi M., Cabras V., Pilloni M., Ennas G.

Centella asiatica extract-SiO2 nanocomposite: More than a drug-delivery system for skin protection from oxidative damage.

J Biomed Mater Res., 1–9, 2022

112.  Manconi M., Rezvani M., Manca M.L., Escribano-Ferrer E., Fais S., Orrù G., Lammers T., Asunis F., Muntoni A., Spiga D., De Gioannis G.

Bridging biotechnology and nanomedicine to produce biogreen whey-nanovesicles for intestinal health promotion.

Int. J. Pharm., 633, 122631, 2023.

113.  Firoznezhad M., Abi-Rached R., Fulgheri F., Aroffu M., Leyva-Jimenez F.J., Cadiz Gurrea M.L., Meloni M.C., Corrias F., Escribano-Ferrer E., Peris J.E., Manca M.L.*, Manconi M.

Design and in vitro effectiveness evaluation of Echium amoenum extract loaded in bioadhesive phospholipid vesicles tailored for mucosal delivery

Int. J. Pharm., 634, 122650, 2023.

114. Sklenarova R., Allaw M., Perra M., Castangia I., Frankova J., Pedraz J.L., Manca M.L.*, Manconi M.

Co-delivering of oleuropein and lentisk oil in phospholipid vesicles as an effective approach to modulate oxidative stress, cytokine secretion and promote skin regeneration.

European Journal of Pharmaceutics and Biopharmaceutics, 185, 126-136, 2023.

115.  Perra M., Leyva-Jiménez F.J., Manca M.L., Manconi M., Rajha H.N., Borrás-Linares I., Segura-Carretero A., Lozano-Sánchez J.

Application of pressurized liquid extraction to grape by-products as a circular economy model to provide phenolic compounds enriched ingredient.

Journal of Cleaner Production, 402, 13672, 2023.

116.  Román-Álamo L., Allaw M. , Avalos-Padilla Y., Manca M.L., Manconi M., Fulgheri F., Fernández-Lajo J., Rivas L., Vázquez J.A., Peris J.E., Roca-Geronès X, Poonlaphdecha S., Alcover M.M., Fisa R., Riera C., Fernàndez-Busquets X.

In vitro evaluation of aerosol therapy with pentamidine loaded liposomes coated with chondroitin sulfate or heparin for the treatment of leishmaniasis.

Pharmaceutics, 15, 1163, 2023.

 

Patents

Zaru M, Manca M.L., Fadda AM, Orsini G.

Glycerosomes and use thereof in pharmaceutical and cosmetic preparations for topical application.

Italian Patent                                       IT 0001398268           22.02.2013

European Patent                                 EP 2405896 B1          07.05.2014

United States Patent                        US 8778367 B2           15.07.2014

 

Manca M.L., Manconi M., Zaru M., Castangia I., Cabras A., Cappai N., Fadda A.M.

Ialurosomi, loro uso in composizioni topiche farmaceutiche o cosmetiche e relativo procedimento di preparazione

Italian Patent                                       IT 0001427462 27.02.2017

European Patent                                EP 3025732 B1 27.03.2019

 

Manca M.L., Manconi M., Fadda A.M.

Aggregati vescicolari tridimensionali di fosfolipidi dispersi in miscele alcoliche a basso o nullo contenuto d’acqua, loro preparazione e loro uso in formulazioni per applicazione topica

Italian Patent                                       IT102017000034725   16.07.2019                                 

European Patent Application           EP18163201.9              21.03.2018

 

Manconi M., Manca M.L., Caddeo C., Fadda A.M.

Complessi a base di fosfolipidi, fibre idrosolubili e principi attivi antiossidanti di origine naturale, loro preparazione e uso in formulazioni orali

Italian Patent                                     IT102017000059875    30.09.2019

European Patent Application         EP18174611.6              28.05.2018