Nell’ambito del programma “Visiting Professor” finanziato dalla Regione Autonoma della Sardegna,il Prof. Luciano Boi terrà i seguenti seminari:

 

Ecole des Hautes Etudes en Sciences Sociales Centre de Mathématiques Paris (France)

 

26 Ottobre, 16-18, Aula A Dip.to di Fisica

1) “Introduction to the geometry and physics of DNA: forms, structures and functions”

 

28 Ottobre, 16-18, Aula A Dip.to di Fisica

2) “Topological plasticity and biological complexity of supramolecular structures (proteins-DNA complexes and the chromatin)

 

29 Ottobre, 16-18, Aula C Dip.to di Fisica

3) “Interfaces of mathematical methods and modeling with the physical and life sciences: some open problems and lines of research”

 

 Topological Plasticity, physical dynamics and biological complexity: theory and phenomenology

 General abstract. The lectures are aimed at showing that differential geometry and topological knots theory can be used notably to modeling 3-dimensional structures of DNA and protein-DNA complexes. Our goal is twofold: firstly, we want to show that certain topological deformations associated to the supramolecular structures during the cell cycle take part in the dynamics of chromatin, chromosome and therefore the cell’s metabolism; secondly, we try to illustrate the way in which these deformations might modulate the action of many different regulatory systems, ensuring in particular the transition of this action from a local-target mechanisms to global functional processes. We shall argue that these interactions between topological changes and dynamic processes constitute a deep and largely unexplored meeting point between mathematics, physics of complex systems and biological sciences. Further, we suggest that certain geometric properties and topological patterns work like dynamic principles, which are involved in the organization and growth of living systems. Moreover, these properties and patterns display intricate physical and biological complexity on every scale from very large (i.e. the organism) to very small (i.e. the molecule), and also contribute to the multilayer ordering of biological regulation and activity.