Metabolic interactions between vitamin A and conjugated linoleic acid
CARTA, GIANFRANCAFirst
;MURRU, MARIA ELISABETTA;BANNI, SEBASTIANO
2014-01-01
Abstract
Lipid-soluble molecules share several aspects of their physiology due to their common adaptations to a hydrophilic environment, and may interact to regulate their action in a tissue-specific manner. Dietary conjugated linoleic acid (CLA) is a fatty acid with a conjugated diene structure that is found in low concentrations in ruminant products and available as a nutritional supplement. CLA has been shown to increase tissue levels of retinol (vitamin A alcohol) and its sole specific circulating carrier protein retinol-binding protein (RBP or RBP4). However, the precise mechanism of this action has not been elucidated yet. Here, we provide a summary of the current knowledge in this specific area of research and speculate that retinol and CLA may compete for catabolic pathways modulated by the activity of PPAR- and RXR heterodimer. We also present preliminary data that may position PPAR- at the crossroads between the metabolism of lipids and vitamin AFile | Size | Format | |
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nutrients vit A and CLA review.pdf open access
Type: versione editoriale
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2.04 MB | Adobe PDF | View/Open |
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