Biphosphonates-related osteonecrosis of the jaw: multicenter study

PIRAS, VINCENZO;Brunelli G;Carinci F;Piras A;Brugnati C;Orani L;Marini M;GARAU, VALENTINO;DENOTTI, GLORIA

2012-01-01

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Abstract

Biphosphonates-related osteonecrosis of the jaw is defined as an exposure of necrotic bone in maxillofacial region,which persists more than 8 weeks in patients treated or,in course of treatment whit biphosphonate, not been subjected to radiation therapy of the jaw . Biphosphonate compounds used to treat osteoporosis and malignant bone metastasis.despite yhe benefits related to the use of these medications ,osteonecrosis of the jaw is a significant complication in a subset of patients receiving these drugs. This complication occurs either spontaneously or after a simple dento-alveolar surgery. This study was conducted to evaluate the correlation between the onset of onj and biphosphonate treatment,through descriptive and statistical data analysis, extracted from our study population,and correlation with data offered by literature.