Vesicle formation from hexasubstituted cyclophosphazenic derivatives

BAROLI, BIANCA MARIA;DELOGU, GIOVANNA LUCIA;FADDA, ANNA MARIA;Podda G;SINICO, CHIARA

1999-01-01

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Abstract

Hexakis[butoxytris(ethoxy)]cyclophosphazene (3a), hexakis[dodecyloxytetrakis (ethoxy)]cyclophosphazene (3b) and hexakis[hexadecyloxyeicosanekis(ethoxy)]cyclophosphazene (3c) were synthesised and their ability to form niosomes was studied. All synthesised compounds in the presence of cholesterol were shown to form vesicles; which aggregated strongly. To prevent aggregation, dicetylphosphate was used. The capacity of the sonicated and unsonicated niosomes to encapsulate hydrophile and lipophile molecules was also studied using carboxyfluorescein and diphenylhexatriene. (C) 1999 Elsevier Science B.V. All rights reserved.