New halogenated phenylcoumarins as tyrosinase inhibitors

Matos MJ;Santana L;Uriarte E;DELOGU, GIOVANNA LUCIA;CORDA, MARCELLA;Fadda MB;ERA, BENEDETTA;FAIS, ANTONELLA

2011-01-01

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Abstract

With the aim to find out structural features for the tyrosinase inhibitory activity, in the present communication we report the synthesis and pharmacological evaluation of a new series of phenylcoumarin derivatives with different number of hydroxyl or ether groups and bromo substituent in the scaffold. The synthesized compounds 5-12 were evaluated as mushroom tyrosinase inhibitors showing, two of them, lower IC 50 than the umbelliferone. Compound 12 (IC 50 = 215 μM) is the best tyrosinase inhibitor of this series.