Molecular dynamics computer simulations of multidrug RND efflux pumps

RUGGERONE, PAOLO;VARGIU, ATTILIO VITTORIO;
2013-01-01

Abstract

Over-expression of multidrug efflux pumps of the Resistance Nodulation Division (RND) protein super family counts among the main causes for microbial resistance against pharmaceuticals. Understanding the molecular basis of this process is one of the major challenges of modern biomedical research, involving a broad range of experimental and computational techniques. Here we review the current state of RND transporter investigation employing molecular dynamics simulations providing conformational samples of transporter components to obtain insights into the functional mechanism underlying efflux pump-mediated antibiotics resistance in Escherichia coli and Pseudomonas aeruginosa.
2013
Inglese
5
6
11
2-s2.0-84890928482
24688701
http://journals.sfu.ca/rncsb/index.php/csbj/article/view/csbj.201302008/228
Esperti anonimi
internazionale
scientifica
Multidrug resistance; Molecular dynamics simulations; Efflux systems
sì
Ruggerone, Paolo; Vargiu, ATTILIO VITTORIO; Collu, F; Fischer, N; Kandt, C.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
5
open
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