Cytotoxic phloroglucinols from the leaves of Myrtus communis

COTTIGLIA, FILIPPO;CASU, LAURA;LEONTI, MARCO;CABONI, PIERLUIGI;FLORIS, COSTANTINO;Busonera B;FARCI, PAMELA;Ouhtit A;SANNA, GIUSEPPINA

2012-01-01

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Abstract

Bioactivity-guided fractionation of a dichloromethane extract of the leaves of Myrtus communis led to the isolation of phloroglucinol derivatives. The structures of the new myrtucommulones J, K, and L (1-3) and the previously known myrtucommulone A (4) were elucidated on the basis of extensive 1D and 2D NMR experiments as well as high-resolutionmass spectrometry. Myrtucommulone J was obtained as a tautomeric pair (1/1a). The compounds were tested in vitro for their cytotoxic and antibacterial activities.