No evidence of association between dopamine D3 receptor gene and bipolar affective disorder

PICCARDI MP;SEVERINO, GIOVANNI;BOCCHETTA, ALBERTO;PALMAS MA;RUIU S;DEL ZOMPO, MARIA

1997-01-01

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Abstract

A recent study reported a possible association between allele 1 of the dopamine D3 receptor gene and bipolar affective disorder using the haplotype relative risk approach. In attempt to replicate these findings, we used similar family-based methods, such as the Haplotype-Based Haplotype Relative Risk method and the Transmission Disequilibrium Test, in a sample of 44 bipolar probands from Sardinia with both parents available. Using the Bal I restriction enzyme site polymorphism of Lannfelt et al. (1992), no differences were found between transmitted and non.transmitted alleles and no evidence of linkage disequilibrium was observed.