Opioid peptides: Structure-activity relationships of dermorphin endothiotetrapeptides. VII

SALVADORI S;MARASTONI M;BALBONI, GIANFRANCO;TOMATIS R;SARTO G.

1984-01-01

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Abstract

We describe the synthesis and preliminary in vitro and in vivo pharmacological tests of five endothiotetrapeptide analogues of the opioid heptapeptide dermorphin H-Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser.-NH2. The modification obtained by substituting Phet for Phe3 or Glyt for Gly4 provided further analogues with significant opioid activity.