Structure-activity ralationships of cyclic and linear peptide T analogues

MARASTONI M;SALVADORI S;BALBONI, GIANFRANCO;SCARANARI V;SPISANI S;REALI E;TRANIELLO S;TOMATIS R.

1993-01-01

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Abstract

Using the potent cyclic peptide T analog [formula: see text] as parent compound, a series of analogues were synthesized and their potencies in a monocyte chemotaxis assay were compared with those of correspondingly modified linear peptides. Structure-activity relationships observed with cyclic compounds did not always parallel those determined with linear analogues. [formula: see text] showed the highest affinity to CD4 receptor of monocytes of any peptide thus far studied. It also proved to be highly resistant to degradation by plasma or brain enzymes.