Synthesis and activity of dermorphin-growth hormone releasing factor hybrid peptides

MARASTONI M;SALVADORI S;BALBONI, GIANFRANCO;BOREA PA;TOMATIS R.

1989-01-01

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Abstract

Dermorphin- growth hormone releasing factor (GRF) hybrid peptides (Y-Tyr-D-Ala-Xaa-Gly-Tyr-Pro-Ser-NH2) were synthesized and tested for opioid activity and their ability to stimulate growth hormone (GH) secretion. The substitution of Phe3 for Asp and Glu in dermorphin or its N-terminal acetylation produced peptides with no affinity for opioid receptors but significant, even if low, GRF-like activity.