Structure-activity relationships of peptide T-related pentapeptides

MARASTONI M;SALVADORI S;BALBONI, GIANFRANCO;SPISANI S;GAVIOLI R;TRANIELLO S;TOMATIS R.

1989-01-01

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Abstract

Fifteen pentapeptide analogs of C-terminal fragment of peptide T, H-Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr-OH, were prepared and tested for human monocyte chemotaxis. Structure-activity studies suggest that the potent chemotactic activity of H-Thr-Thr-Asn-Tyr-Thr-OH is mediated through the polar properties of the C-terminal carboxyl group and Thr side chains at the critical positions 5 and 8, while the hydroxyl group of N-terminal Thr and its free amino function are not essential requirements for CD4 receptor interactions.