Anti-thyroid drug methimazole: X-ray characterisation of two novel ionic disulfides obtained from its chemical oxidation by I2

ARAGONI, MARIA CARLA;ARCA, MASSIMILIANO;ISAIA, FRANCESCO;LIPPOLIS, VITO;
2002-01-01

Abstract

Interaction of methimazole (MMI, 1-methyl-imidazole-2-thione) with I2 in solvents having different polarity gives two new stable compounds containing a dication disulfide and a monocation disulfide arranged in dimers, respectively. These two species could represent effective intermediates in the reaction of MMI with an active iodine species in the thyroid gland and therefore shed more light on the mechanism of action of MMI as an antithyroid drug.
2002
Inglese
124
17
4538
4539
2
WOS:000175227600002
2-s2.0-0036569582
11971682
Esperti anonimi
internazionale
scientifica
no
Aragoni, MARIA CARLA; Arca, Massimiliano; F., Demartin; F. A., Devillanova; A., Garau; Isaia, Francesco; Lippolis, Vito; G., Verani
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
8
reserved
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