Mechanosynthesis of sulfonamides via a telescopic, environmentally friendly, and cost-effective process

Cuccu F.

First

Investigation

;Porcheddu A.

Last

Conceptualization

2024-01-01

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Abstract

Herein, we demonstrate a solvent-free mechanochemical approach involving a one-pot-double-step procedure mediated by solid sodium hypochlorite (NaOCl·5H2O) for the synthesis of sulfonamides. The protocol entails a tandem oxidation-chlorination reaction on disulfides in the presence of a catalytic solid acidic species, followed by an amination prompted by a Lewis acid-base solid inorganic reagent. The methodology works smoothly with aromatic and aliphatic disulfides and amines. The purification process pays due attention to environmental concerns and avoids harsh conditions to obtain pure sulfonamide products. Some relevant biologically active compounds have been prepared with this procedure.