Maria Chiara Di Guardo
Serotonin/dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesia: An update
Corsi, Sara;Stancampiano, Roberto;Carta, Manolo
2021-01-01
Abstract
: Ample evidence suggests that the serotonergic system plays a major role in several aspects of Parkinson's disease. In this review, we focus on the interplay between dopamine and serotonin in the appearance of L-DOPA-induced dyskinesia (LID), the most troublesome side effect of L-DOPA therapy. Indeed, while this drug exerts significant amelioration of motor symptoms during the first few years of treatment, eventually, most of patients experience dyskinesias, which limit the use of L-DOPA in advanced stages of disease. Here, we present the mechanisms underlying LID and the role of serotonin neurons, review preclinical and clinical data, and discuss possible therapeutic strategies.Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.