Phytochemical Analysis and In Vitro Antileukemic Activity of Alkaloid-Enriched Extracts from Vinca sardoa (Stearn) Pignatti

De Vita, Daniela;Frezza, Claudio;Sciubba, Fabio;Toniolo, Chiara;Badiali, Camilla;Petrucci, Rita;Bortolami, Martina;Di Matteo, Paola;Rocco, Daniele;Stringaro, Annarita;Colone, Marisa;Maxia, Andrea;Petrucci, Maria Teresa;Serafini, Mauro;Foddai, Sebastiano

2023-01-01

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Abstract

Vinca sardoa (Stearn) Pignatti, known as Sardinian periwinkle, is widely diffused in Sardinia (Italy). This species contains indole alkaloids, which are known to have a great variety of biological activities. This study investigated the antileukemic activity against a B lymphoblast cell line (SUP-B15) of V. sardoa alkaloid-rich extracts obtained from plants grown in Italy, in Iglesias (Sardinia) and Rome (Latium). All the extracts showed a good capacity to induce reductions in cell proliferation of up to 50% at the tested concentrations (1-15 & mu;g/mL). Moreover, none of the extracts showed cytotoxicity on normal cells at all the studied concentrations.