Caterina Fenu
Effects of cytotoxic T-lymphocyte-associated protein 4 compared to TNF inhibitors on lipid profile: Results from an observational multicentre rheumatoid arthritis cohort
Piga M.Writing - Review & Editing
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2024-01-01
Abstract
Aim: To evaluate the impact of selective cytotoxic T-lymphocyte-associated protein 4 (CTLA-4Ig) compared to tumor necrosis factor inhibitors (TNFi) on cardiovascular (CV) clinical and laboratory outcomes in patients with rheumatoid arthritis (RA). Methods: We performed a prospective observational multicenter study of RA patients included in the "Cardiovascular Obesity and Rheumatic DISease (CORDIS)" Study Group database, collecting demographic, clinical, and laboratory data of those starting a CTLA-4Ig or TNFi at baseline, 6-month, and 12-month follow-up. Results: Of the 206 RA patients without previous CV events enrolled in the study, 64 received a CTLA-4Ig and 142 a TNFi. The two groups did not differ in age, gender, or smoking habits, and the prevalence of hypertension, diabetes, and metabolic syndrome was similar. Over a follow-up period of 12 months, although no significant differences were found in the disease activity course, we observed that LDL cholesterol levels slightly decreased only in the CTLA-4Ig-treated patients. Conclusions: Patients treated with both CTLA-4Ig and TNFi did not differ in disease activity response and changes in traditional CV risk factors after 12 months of treatment. However, CTL-A-4Ig treatment is associated with a favorable change in lipid profile at 12-month follow-up.File | Size | Format | |
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Atzeni F - Abatacept and others TNFi PRE-PRINT.pdf open access
Type: versione pre-print
Size 373.92 kB
Format Adobe PDF
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373.92 kB | Adobe PDF | View/Open |
Atzeni F - Effects of cytotoxic T-lymphocyte-associated protein 4 compared to TNF inhibitors on lipid profile.pdf Solo gestori archivio
Type: versione editoriale
Size 1.08 MB
Format Adobe PDF
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1.08 MB | Adobe PDF | & nbsp; View / Open Request a copy |
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