Infections in lung cancer patients undergoing immunotherapy and targeted therapy: an overview on the current scenario

Bertaglia, Valentina;Morelli, Anna Maria;Solinas, Cinzia;Aiello, Marco Maria;Manunta, Silvia;Denaro, Nerina;Tampellini, Marco;Scartozzi, Mario;Novello, Silvia

2023-01-01

---

Abstract

Patients with a diagnosis of lung cancer are often vulnerable to infection, and the risk is increased by tumor-associated immunosuppression and the effects of the treatments. Historically, links between the risk of infection and cytotoxic chemotherapy due to neutropenia and respiratory syndromes are well established. The advent of tyrosine kinase inhibitors (TKIs) and immune-checkpoint inhibitors (ICIs) targeting the programmed cell death-1 (PD-1)/programmed cell death- ligand 1 (PD-L1) axis and cytotoxic T-lymphocyte antigen-4 (CTLA-4) have changed the treatment paradigm for lung cancer patients. Our understanding of the risk of infections while administrating these drugs is evolving, as are the biological mechanisms that are responsible. In this overview, we focus on the risk of infection with the use of targeted therapies and ICIs, summarizing current evidence from preclinical and clinical studies and discussing their clinical implications.