Mechanochemical Fischer Indolisation: an Eco-friendly Design for a Timeless Reaction
Porcheddu, AndreaFirst
;Mocci, Rita
;Cuccu, Federico;Fattuoni, Claudia;Delogu, Francesco;D'Auria, Maria ValeriaLast
2022-01-01
Abstract
We developed an environmentally friendly mechanochemical protocol to induce an effective Fischer indolisation to synthesize indoles and indolines taking advantage of oxalic acid and dimethylurea. The solvent-free procedure shows versatility and wide scope; it applies to a broad range of arylhydrazines and carbonyl compounds, leading to variously decorated indoles and indolenines. Upon suitable modification, the methodology can also allow preparing compounds of pharmaceutical interest.File | Size | Format | |
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d2gc00724j.pdf Solo gestori archivio
Description: articolo online (first)
Type: versione editoriale
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1.38 MB | Adobe PDF | & nbsp; View / Open Request a copy |
d2gc00724j-1.pdf open access
Type: versione editoriale
Size 2.52 MB
Format Adobe PDF
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2.52 MB | Adobe PDF | View/Open |
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