Effect of Manual Grinding on Diclofenac Acid Nanocrystals: A Chemico-Physical Investigation

Scano, Alessandra

Co-prime

Member of the Collaboration Group

;Lai, Francesco

Member of the Collaboration Group

;Marongiu, Francesca

Member of the Collaboration Group

;Ennas, Guido

Co-prime

Member of the Collaboration Group

2021-01-01

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Abstract

X-ray Powder Diffraction, Fourier Transform Infrared Spectroscopy and Differential Scanning Calorimeter were used to study the effect of the manual grinding in an agate mortar of the diclofenac acid polymorphs HD1 and HD2. In particular, we have tried to highlight how the HD2 form is more sensitive than the HD1 to the grinding process to achieve a nanometric crystal size. HD1 shows no change, while in the case of the HD2, changes in the molecular conformation and the formation of a new metastable form of the polymorph are observed after grinding.