The Role of Peripheral Cells in Neurocognitive Disorders Detection

Francesco Salis

First

;Antonella Mandas

Last

Supervision

2021-01-01

---

Abstract

Neurocognitive Disorders (NCDs) epidemiological data are distinctly alarming, testimony as they are to a marked increase in NCDs incidence, which will continue to be observed. In order to enable patients to benefit from possible therapies, it is vital to have the capacity for early disorders interception and for severity increase prediction. Accurate studies in this regard spotlight strategies’ highly invasive nature and spiraling costs, which factors hinder their widespread employment. Consequently, there is increasing interest, in this connection, in easily accessible biological matrices. The aim of the present review is to analyze the possible role of these matrices’ cellular, as opposed to fluid, component in clinical practice. We will therefore explore, in particular, the role played by various peripheral cells in screening, diagnosis, and follow-up. Reference will be made to a number of significant studies which highlight the importance of these cells as borne out by recent scientific literature. Peripheral Blood Mononuclear Cells (PBMNCs) and platelets, together with oral mucosa cells were at the centre of our focus.