Protective Agents in Parkinson’s Disease: Caffeine and Adenosine A2A Receptor Antagonists

Simola, Nicola

First

Writing - Review & Editing

;Pinna, Annalisa

Writing - Original Draft Preparation

;Frau, Lucia

Writing - Original Draft Preparation

;Costa, Giulia

Writing - Original Draft Preparation

;Marongiu, Jacopo

Writing - Original Draft Preparation

;Parekh, Pathik

Writing - Original Draft Preparation

;Serra, Marcello

Writing - Original Draft Preparation

;Morelli, Micaela

Last

Writing - Review & Editing

2021-01-01

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Abstract

Based on several findings suggesting that the adenosinergic system is one of the most interesting in the field of neuroprotection in Parkinson’s disease, this chapter describes the functions of the purine adenosine and its A2A receptors in the central nervous system, with emphasis on their role in neuroprotection. The neuromodulatory role of A2A receptors and the preclinical and epidemiological studies on the mechanisms of the neuroprotective role of caffeine and urate, the final product of purine catabolism, are extensively discussed in the light of their potential modifying effects on Parkinson’s disease.