Metal complex formation and anticancer activity of cu(I) and cu(ii) complexes with metformin

Marcello Campagna;Joanna Izabela Lachowicz
2021-01-01

Abstract

Metformin has been used for decades in millions of type 2 diabetes mellitus patients. In this time, correlations between metformin use and the occurrence of other disorders have been noted, as well as unpredictable metformin side effects. Diabetes is a significant cancer risk factor, but unexpectedly, metformin-treated diabetic patients have lower cancer incidence. Here, we show that metformin forms stable complexes with copper (II) ions. Both copper(I)/metformin and copper(II)/metformin complexes form adducts with glutathione, the main intracellular antioxidative peptide, found at high levels in cancer cells. Metformin reduces cell number and viability in SW1222 and K562 cells, as well as in K562-200 multidrug-resistant cells. Notably, the antiproliferative effect of metformin is enhanced in the presence of copper ions.
2021
Inglese
26
16
4730
1
19
19
Esperti anonimi
internazionale
scientifica
metformin; copper complexes; diabetes; cancer; proliferation; protonation constants; stability constants; glutathione; NMR
Abdelrahman, Sherin; Alghrably, Mawadda; Campagna, Marcello; Armgard Emma Hauser, Charlotte; Jaremko, Mariusz; Lachowicz, JOANNA IZABELA
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
6
open
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