Clot characterization by multidisciplinary approach: biochemical and imaging parameters in a hypocoagulative setting. A pilot study

Marongiu, Francesco;Ntoukas, Dimitrios Marco;Barberini, Luigi;Ruberto, Maria Filomena;Piras, Maria Sebastiana;Conti, Maria;Di Martino, Maria Luisa;Mura, Mario;Marongiu, Silvia;Vannini, Maria Luigia;Lillu, Mattia;Piras, Monica;Fanni, Daniela;Fenu, Lara;Porcu, Carmen;Barcellona, Doris;Faa, Gavino;Congiu, Terenzio

2021-01-01

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Abstract

Clot characterization is, to the present days, a multimodal approach: scanning the clot by electron microscopy (SEM) is helpful for the visualization of fibrin structure along with laboratory parameters such as the clot waveform analysis (CWA) and thrombin generation in different settings of clot abnormalities. This study aimed to assess whether the coagulative parameters were consistent with the clot images texture acquired by SEM, and therefore to propose a more generalist and integrative approach to clots classification.