Azathioprine for prevention of clinical recurrence in Crohn's disease patients with severe endoscopic recurrence: an IG-IBD randomized double-blind trial

Orlando, A;Mocciaro, F;Ventimiglia, M;Renna, S;Rispo, A;Scribano, M L;Testa, A;Aratari, A;Bossa, F;Angelucci, E;Onali, S;Cappello, M;Giunta, M;Macaluso, F S;Scimeca, D;Macaluso, F;Castiglione, F;Papi, C;Annese, V;Biancone, L;Kohn, A;Di Mitri, R;Cottone, M

2020-01-01

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Abstract

The recurrence of Crohn's Disease after ileo-colonic resection is a crucial issue. Severe endoscopic lesions increase the risk of developing early symptoms. Prevention and treatment of post-operative Endoscopic Recurrence (ER) have been studied with conflicting results. We compare effi cacy of azathioprine (AZA) vs. high-dose 5-aminosalicylic acid (5-ASA) in preventing clinical recurrence and treating severe post-operative ER.