Mechanochemical Preparation of Active Pharmaceutical Ingredients Monitored by In Situ Raman Spectroscopy

Sović, Irena

Member of the Collaboration Group

;Lukin, Stipe

Member of the Collaboration Group

;Meštrović, Ernest

Member of the Collaboration Group

;Halasz, Ivan

Writing - Review & Editing

;Porcheddu, Andrea;Delogu, Francesco;Ricci, Pier Carlo;Caron, Fabien

Member of the Collaboration Group

;Perilli, Thomas

Member of the Collaboration Group

;Dogan, Anita

Member of the Collaboration Group

;Colacino, Evelina

2020-01-01

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Abstract

The mechanochemical preparation of silver sulfadiazine and dantrolene, two marketed active pharmaceutical ingredients, was investigated by in situ Raman spectroscopy. For the first time, the mechanochemical transformations involving highly fluorescent compounds could be studied in situ with a high-resolution Raman system combined with a unique suitable Raman probe. Moreover, the kinetic features of the mechanochemical process were examined by a mathematical model allowing to describe the chemical changes under mechanical stress. This approach is promising both to broaden the scope of Raman in situ investigations that would otherwise be impossible and for process optimization at any scale.