Solvent-free, continuous synthesis of hydrazone-based active pharmaceutical ingredients by twin-screw extrusion

Porcheddu A.;Delogu F.
Member of the Collaboration Group
;Colacino E.
Writing - Review & Editing
2020-01-01

Abstract

Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.
2020
active pharmaceutical ingredients (APIs); green chemistry; hydantoins; hydrazones; mechanochemistry; solven ree; twin-screw extrusion (TSE)
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