Solvent-free, continuous synthesis of hydrazone-based active pharmaceutical ingredients by twin-screw extrusion

Porcheddu A.;Delogu F.
Member of the Collaboration Group
;Colacino E.
Writing - Review & Editing
2020-01-01

Abstract

Twin-screw extrusion (TSE) was used to synthesize hydantoin-based active pharmaceutical ingredients (APIs) such as nitrofurantoin and dantrolene, employing minimal or no solvent. Postsynthetic workup was not required. This work demonstrates that solvent-free synthesis can be conducted in a continuous manner for pharmaceutical products.
2020
Inglese
8
32
12230
12238
9
WOS:000562983600038
2-s2.0-85090979600
Esperti anonimi
internazionale
scientifica
active pharmaceutical ingredients (APIs); green chemistry; hydantoins; hydrazones; mechanochemistry; solven ree; twin-screw extrusion (TSE)
sì
Crawford, D. E.; Porcheddu, A.; Mccalmont, A. S.; Delogu, F.; James, S. L.; Colacino, E.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
6
reserved
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