Unravelling the interplay between hyperkalaemia, renin-angiotensin-aldosterone inhibitor use and clinical outcomes. Data from 9222 chronic heart failure patients of the ESC-HFA-EORP Heart Failure Long-Term Registry

Rossignol, Patrick;Lainscak, Mitja;Crespo-Leiro, Maria G;Laroche, Cécile;Piepoli, Massimo F;Filippatos, Gerasimos;Rosano, Giuseppe M C;Savarese, Gianluigi;Anker, Stefan D;Seferovic, Petar M;Ruschitzka, Frank;Coats, Andrew J S;Mebazaa, Alexandre;McDonagh, Theresa;Sahuquillo, Ana;Penco, Maria;Maggioni, Aldo P;Lund, Lars H;Christopher Peter Gale GB;Branko Beleslin RS;Andrzej Budaj PL;Ovidiu Chioncel RO;Nikolaos Dagres DE;Nicolas Danchin FR;David Erlinge SE;Jonathan Emberson GB;Michael Glikson IL;Alastair Gray GB;Meral Kayikcioglu TR;Aldo Maggioni IT;Klaudia Vivien Nagy HU;Aleksandr Nedoshivin RU;Anna-Sonia Petronio IT;Jolien Roos-Hesselink NL;Lars Wallentin SE;Uwe Zeymer DE;Crespo-Leiro M;Anker S;Mebazaa A;Coats A;Filippatos G;Ferrari R;Maggioni AP;Piepoli MF;Goda A;Diez M;Fernandez A;Fruhwald F;Fazlibegovic E;Gatzov P;Kurlianskaya A;Hullin R;Christodoulides T;Hradec J;Nielsen OW;Nedjar R;Uuetoa T;Hassanein M;Jimenez JFD;Harjola VP;Logeart D;Chumburidze V;Tousoulis D;Milicic D;Merkely B;O'Donoghue E;Amir O;Shotan A;Shafie D;Metra M;Matsumori A;Mirrakhimov E;Kavoliuniene A;Erglis A;Vataman E;Otljanska M;Kostovska ES;DeMarco DC;Drozdz J;Fonseca C;Chioncel O;Dekleva M;Shkolnik E;Dahlstrom U;Lainscak M;Goncalvesova E;Temizhan A;Estrago V;Bajraktari G;Auer J;Ablasser K;Fruhwald F;Dolze T;Brandner K;Gstrein S;Poelzl G;Moertl D;Reiter S;Podczeck-Schweighofer A;Muslibegovic A;Vasilj M;Fazlibegovic E;Cesko M;Zelenika D;Palic B;Pravdic D;Cuk D;Vitlianova K;Katova T;Velikov T;Kurteva T;Gatzov P;Kamenova D;Antova M;Sirakova V;Krejci J;Mikolaskova M;Spinar J;Krupicka J;Malek F;Hegarova M;Lazarova M;Monhart Z;Hassanein M;Sobhy M;El Messiry F;El Shazly AH;Elrakshy Y;Youssef A;Moneim AA;Noamany M;Reda A;Dayem TKA;Farag N;Halawa SI;Hamid MA;Said K;Saleh A;Ebeid H;Hanna R;Aziz R;Louis O;Enen MA;Ibrahim BS;Nasr G;Elbahry A;Sobhy H;Ashmawy M;Gouda M;Aboleineen W;Bernard Y;Luporsi P;Meneveau N;Pillot M;Morel M;Seronde MF;Schiele F;Briand F;Delahaye F;Damy T;Eicher JC;de Groote P;Fertin M;Lamblin N;Isnard R;Lefol C;Thevenin S;Hagege A;Jondeau G;Logeart D;Le Marcis V;Ly JF;Coisne D;Lequeux B;Le Moal V;Mascle S;Lotton P;Behar N;Donal E;Thebault C;Ridard C;Reynaud A;Basquin A;Bauer F;Codjia R;Galinier M;Tourikis P;Stavroula M;Tousoulis D;Stefanadis C;Chrysohoou C;Kotrogiannis I;Matzaraki V;Dimitroula T;Karavidas A;Tsitsinakis G;Kapelios C;Nanas J;Kampouri H;Nana E;Kaldara E;Eugenidou A;Vardas P;Saloustros I;Patrianakos A;Tsaknakis T;Evangelou S;Nikoloulis N;Tziourganou H;Tsaroucha A;Papadopoulou A;Douras A;Polgar L;Merkely B;Kosztin A;Nyolczas N;Nagy AC;Halmosi R;Elber J;Alony I;Shotan A;Fuhrmann AV;Amir O;Romano S;Marcon S;Penco M;Di Mauro M;Lemme E;Carubelli V;Rovetta R;Metra M;Bulgari M;Quinzani F;Lombardi C;Bosi S;Schiavina G;Squeri A;Barbieri A;Di Tano G;Pirelli S;Ferrari R;Fucili A;Passero T;Musio S;Di Biase M;Correale M;Salvemini G;Brognoli S;Zanelli E;Giordano A;Agostoni P;Italiano G;Salvioni E;Copelli S;Modena MG;Reggianini L;Valenti C;Olaru A;Bandino S;Deidda M;Mercuro G;Cadeddu Dessalvi C;Marino PN;Di Ruocco MV;Sartori C;Piccinino C;Parrinello G;Licata G;Torres D;Giambanco S;Busalacchi S;Arrotti S;Novo S;Inciardi RM;Pieri P;Chirco PR;Galifi MA;Teresi G;Buccheri D;Minacapelli A;Veniani M;Frisinghelli A;Priori SG;Cattaneo S;Opasich C;Gualco A;Pagliaro M;Mancone M;Fedele F;Cinque A;Vellini M;Scarfo I;Romeo F;Ferraiuolo F;Sergi D;Anselmi M;Melandri F;Leci E;Iori E;Bovolo V;Pidello S;Frea S;Bergerone S;Botta M;Canavosio FG;Gaita F;Merlo M;Cinquetti M;Sinagra G;Ramani F;Fabris E;Stolfo D;Artico J;Miani D;Fresco C;Daneluzzi C;Proclemer A;Cicoira M;Zanolla L;Marchese G;Torelli F;Vassanelli C;Voronina N;Erglis A;Tamakauskas V;Smalinskas V;Karaliute R;Petraskiene I;Kazakauskaite E;Rumbinaite E;Kavoliuniene A;Vysniauskas V;Brazyte-Ramanauskiene R;Petraskiene D;Stankala S;Switala P;Juszczyk Z;Sinkiewicz W;Gilewski W;Pietrzak J;Orzel T;Kasztelowicz P;Kardaszewicz P;Lazorko-Piega M;Gabryel J;Mosakowska K;Bellwon J;Rynkiewicz A;Raczak G;Lewicka E;Dabrowska-Kugacka A;Bartkowiak R;Sosnowska-Pasiarska B;Wozakowska-Kaplon B;Krzeminski A;Zabojszcz M;Mirek-Bryniarska E;Grzegorzko A;Bury K;Nessler J;Zalewski J;Furman A;Broncel M;Poliwczak A;Bala A;Zycinski P;Rudzinska M;Jankowski L;Kasprzak JD;Michalak L;Soska KW;Drozdz J;Huziuk I;Retwinski A;Flis P;Weglarz J;Bodys A;Grajek S;Kaluzna-Oleksy M;Straburzynska-Migaj E;Dankowski R;Szymanowska K;Grabia J;Szyszka A;Nowicka A;Samcik M;Wolniewicz L;Baczynska K;Komorowska K;Poprawa I;Komorowska E;Sajnaga D;Zolbach A;Dudzik-Plocica A;Abdulkarim AF;Lauko-Rachocka A;Kaminski L;Kostka A;Cichy A;Ruszkowski P;Splawski M;Fitas G;Szymczyk A;Serwicka A;Fiega A;Zysko D;Krysiak W;Szabowski S;Skorek E;Pruszczyk P;Bienias P;Ciurzynski M;Welnicki M;Mamcarz A;Folga A;Zielinski T;Rywik T;Leszek P;Sobieszczanska-Malek M;Piotrowska M;Kozar-Kaminska K;Komuda K;Wisniewska J;Tarnowska A;Balsam P;Marchel M;Opolski G;Kaplon-Cieslicka A;Gil RJ;Mozenska O;Byczkowska K;Gil K;Pawlak A;Michalek A;Krzesinski P;Piotrowicz K;Uzieblo-Zyczkowska B;Stanczyk A;Skrobowski A;Ponikowski P;Jankowska E;Rozentryt P;Polonski L;Gadula-Gacek E;Nowalany-Kozielska E;Kuczaj A;Kalarus Z;Szulik M;Przybylska K;Klys J;Prokop-Lewicka G;Kleinrok A;Aguiar CT;Ventosa A;Pereira S;Faria R;Chin J;De Jesus I;Santos R;Silva P;Moreno N;Queirós C;Lourenço C;Pereira A;Castro A;Andrade A;Guimaraes TO;Martins S;Placido R;Lima G;Brito D;Francisco AR;Cardiga R;Proenca M;Araujo I;Marques F;Fonseca C;Moura B;Leite S;Campelo M;Silva-Cardoso J;Rodrigues J;Rangel I;Martins E;Correia AS;Peres M;Marta L;da Silva GF;Severino D;Durao D;Leao S;Magalhaes P;Moreira I;Cordeiro AF;Ferreira C;Araujo C;Ferreira A;Baptista A;Radoi M;Bicescu G;Vinereanu D;Sinescu CJ;Macarie C;Popescu R;Daha I;Dan GA;Stanescu C;Dan A;Craiu E;Nechita E;Aursulesei V;Christodorescu R;Otasevic P;Seferovic PM;Simeunovic D;Ristic AD;Celic V;Pavlovic-Kleut M;Lazic JS;Stojcevski B;Pencic B;Stevanovic A;Andric A;Simić D;Ašanin M;Iric-Cupic V;Jovic M;Davidovic G;Milanov S;Mitic V;Atanaskovic V;Antic S;Pavlovic M;Stanojevic D;Stoickov V;Ilic S;Ilic MD;Petrovic D;Stojsic S;Kecojevic S;Dodic S;Adic NC;Cankovic M;Stojiljkovic J;Mihajlovic B;Radin A;Radovanovic S;Krotin M;Klabnik A;Goncalvesova E;Pernicky M;Murin J;Kovar F;Kmec J;Semjanova H;Strasek M;Iskra MS;Ravnikar T;Suligoj NC;Komel J;Fras Z;Jug B;Glavic T;Losic R;Bombek M;Krajnc I;Krunic B;Horvat S;Kovac D;Rajtman D;Cencic V;Letonja M;Winkler R;Valentincic M;Melihen-Bartolic C;Bartolic A;Vrckovnik MP;Kladnik M;Pusnik CS;Marolt A;Klen J;Drnovsek B;Leskovar B;Anguita MJF;Page JCG;Martinez FMS;Andres J;Bayes-Genis A;Mirabet S;Mendez A;Garcia-Cosio L;Roig E;Leon V;Gonzalez-Costello J;Muntane G;Garay A;Alcade-Martinez V;Fernandez SL;Rivera-Lopez R;Puga-Martinez M;Fernandez-Alvarez M;Serrano-Martinez JL;Crespo-Leiro M;Grille-Cancela Z;Marzoa-Rivas R;Blanco-Canosa P;Paniagua-Martin MJ;Barge-Caballero E;Cerdena IL;Baldomero IFH;Padron AL;Rosillo SO;Gonzalez-Gallarza RD;Montanes OS;Manjavacas AMI;Conde AC;Araujo A;Soria T;Garcia-Pavia P;Gomez-Bueno M;Cobo-Marcos M;Alonso-Pulpon L;Cubero JS;Sayago I;Gonzalez-Segovia A;Briceno A;Subias PE;Hernandez MV;Cano MJR;Sanchez MAG;Jimenez JFD;Garrido-Lestache EB;Pinilla JMG;de la Villa BG;Sahuquillo A;Marques RB;Calvo FT;Perez-Martinez MT;Gracia-Rodenas MR;Garrido-Bravo IP;Pastor-Perez F;Pascual-Figal DA;Molina BD;Orus J;Gonzalo FE;Bertomeu V;Valero R;Martinez-Abellan R;Quiles J;Rodrigez-Ortega JA;Mateo I;ElAmrani A;Fernandez-Vivancos C;Valero DB;Almenar-Bonet L;Sanchez-Lazaro IJ;Marques-Sule E;Facila-Rubio L;Perez-Silvestre J;Garcia-Gonzalez P;Ridocci-Soriano F;Garcia-Escriva D;Pellicer-Cabo A;de la Fuente Galan L;Diaz JL;Platero AR;Arias JC;Blasco-Peiro T;Julve MS;Sanchez-Insa E;Aured-Guallar C;Portoles-Ocampo A;Melin M;Hägglund E;Stenberg A;Lindahl IM;Asserlund B;Olsson L;Dahlström U;Afzelius M;Karlström P;Tengvall L;Olsson B;Kalayci S;Temizhan A;Cavusoglu Y;Gencer E;Yilmaz MB;Gunes H.

2020-01-01

---

Abstract

We assessed the interplay between hyperkalaemia (HK) and renin-angiotensin-aldosterone system inhibitor (RAASi) use, dose and discontinuation, and their association with all-cause or cardiovascular death in patients with chronic heart failure (HF). We hypothesized that HK-associated increased death may be related to RAASi withdrawal.