Oral human papilloma virus infection: an overview of clinical-laboratory diagnosis and treatment

G. ORRÙ

First

Conceptualization

;A. MAMELI

Second

Investigation

;C. DEMONTIS

Data Curation

;P. ROSSI

Conceptualization

;D. RATTO

Software

;A. OCCHINEGRO

Methodology

;V. PIRAS

Conceptualization

;L. KUQI

Validation

;M. BERRETTA

Validation

;R. TAIBI

Methodology

;A. SCANO

Penultimate

Conceptualization

;P. CONI

Last

Conceptualization

2019-01-01

---

Abstract

Abstract. – OBJECTIVE: The aim of this review is to describe the “hot points” of current clinical governance for oral HPV comprising the use of new diagnostic molecular procedures, namely, Pyrosequencing and Next Generation Sequencing. MATERIALS AND METHODS: The data on oral HPV was collected through two levels of research. First for all, we used the canonical medical search engines, PubMed, and Medline, followed by the study of current commercial tools for HPV diagnosis, particularly within commercial companies involved in the molecular procedures for HPV detecting and genotyping. RESULTS: Different medical procedures are now described and used throughout the world in HPV diagnosis and treatment. However, the laboratory methods are often validated and used for genital infections, and, in these cases, data are missing in the literature as regards the clinical approach for oral lesions. CONCLUSIONS: Dental care units are often the front line for a clinical evaluation of a possible HPV lesion in the oral cavity, which means that correct clinical governance could avoid a viral neoplastic progression of this disease with great advantages for the patient. In this case, the problem is due to the difficulty in lesion recognition but also and more especially the absence of correct laboratory diagnosis and subsequent treatment in the clinical course.