From enabling technologies to medicinal mechanochemistry: An eco-friendly access to hydantoin-based active pharmaceutical ingredients

Colacino E.

First

Writing - Original Draft Preparation

;Porcheddu A.

Second

Conceptualization

;Charnay C.

Penultimate

Member of the Collaboration Group

;Delogu F.

Last

Investigation

2019-01-01

---

Abstract

The preparation of hydantoin scaffolds using modern non-conventional activation methods is herein described. Special attention is devoted to the preparation of hydantoin-based Active Pharmaceutical Ingredients (APIs) by mechanochemistry, highlighting its advantages compared to classical solution procedures, opening new perspectives in the sustainable preparation of useful scaffolds for the pharmaceutical industry.