Synthesis and in vitro antiviral studies of bis(pivaloyloxymethyl)ester derivative of 9-[((phosphonomethyl)aziridin-1-yl)methyl]adenine(PMAMA) and analogues

ABU SHEIKHA GM;BKHAITAN MM;AL HOURANI RA;QAISI AM;LODDO, ROBERTA;LA COLLA P.

2007-01-01

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Abstract

Bis(pivaloyloxymethyl) ester derivative of 9-{((Phosphonomethyl)aziridin-1- yl)methyl}adenine, (bis(POM)PMAMA) (1), is an analogue of adefovir dipivoxil and tenofovir disoproxil. Compounds 2, 3, and 4 were prepared in similar way to 1.They were tested in vitro against a wide range of viruses, in particularly against HIV-1 and hepatitis viruses.