Dopamine hypersensitivity in migraine: role in apomorphine syncope

DEL ZOMPO, MARIA;M. LAI;V. LOI;M. R. PISANO

1995-01-01

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Abstract

There is some evidence supporting a potential role of hypersensitivity of the dopaminergic system in the pathogenesis of migraine. In this case report, we describe a syncopal episode in a patient with migraine without aura after the administration of a very low dose of apomorphine, a classical agonist of dopaminergic receptors. The absence of cardiovascular risk factors in this patient suggests that the clinical event might have been caused by hypersensitivity of the dopaminergic system.