Disubstituted 4-chloro-3-nitrophenylthiourea derivatives: antimicrobial and cytotoxic studies

Bielenica A;Sanna G

Co-prime

;MADEDDU, SILVIA;Giliberti G;Stefańska J;Kozioł AE;Savchenko O;Strzyga-Łach P;Chrzanowska A;Kubiak-Tomaszewska G;Struga M

2018-01-01

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Abstract

4-Chloro-3-nitrophenylthioureas 1⁻30 were synthesized and tested for their antimicrobial and cytotoxic activities. Compounds exhibited high to moderate antistaphylococcal activity against both standard and clinical strains (MIC values 2⁻64 μg/mL). Among them derivatives with electron-donating alkyl substituents at the phenyl ring were the most promising. Moreover, compounds 1⁻6 and 8⁻19 were cytotoxic against MT-4 cells and various other cell lines derived from human hematological tumors (CC50 ≤ 10 μM). The influence of derivatives 11, 13 and 25 on viability, mortality and the growth rate of immortalized human keratinocytes (HaCaT) was observed.