Influence of the milling parameters on the nucleophilic substitution reaction of activated β-cyclodextrins

Porcheddu, Andrea
Member of the Collaboration Group
;
Delogu, Francesco;Colacino, Evelina
2017-01-01

Abstract

The present work focuses on the mechanochemical preparation of industrially important β-cyclodextrin (CD) derivatives. Activated CDs have been reacted with nitrogen and sulfur nucleophiles using a planetary mill equipped with stainless steel, zirconia and glass milling tools of different sizes. It is shown that the milling frequency and the number as well as the size of the milling balls have an effect on the nucleophilic reaction.
2017
Cyclodextrins; Milling parameters; Nucleophilic substitution; Planetary ball mill; Organic chemistry
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