Ball-milling and cheap reagents breathe green life into the one hundred-year-old Hofmann reaction

Rita Mocci;Sergio Murgia;Evelina Colacino
Member of the Collaboration Group
;Francesco Delogu;Andrea Porcheddu
2018-01-01

Abstract

The Hofmann carbylamine reaction is a very attractive route for preparing isocyanides directly from primary amines. However, its environmentally friendly potential is reduced by the use of hazardous chloroform in large excess. Herein, we report an innovative and very efficient mechanically activated synthesis of isocyanides based on the reaction of amines with chloroform in the presence of solid NaOH and without extra-solvent addition.
2018
2017
Inglese
ORGANIC CHEMISTRY FRONTIERS
5
4
531
538
8
WOS:000431292400002
2-s2.0-85042068297
http://pubs.rsc.org/en/content/articlelanding/2018/qo/c7qo01006k/unauth#!divAbstract
Esperti anonimi
internazionale
scientifica
Hofmann; carbylamine; isocyanide; Ball-milling
no
Mocci, Rita; Murgia, Sergio; De Luca, Lidia; Colacino, Evelina; Delogu, Francesco; Porcheddu, Andrea
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
6
reserved
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