ORAL MICROBIOME PROFILE IN RHEUMATOID ARTHRITIS PATIENTS: ASSOCIATION BETWEEN TONGUE BIOFILM PORPHYROMONAS GINGIVALIS AMOUNT AND DISEASE ACTIVITY

F. Ceccarelli;G. Orrù

Second

Methodology

;A. Pilloni

Conceptualization

;I. Bartosiewicz;C. Perricone

Member of the Collaboration Group

;E. Martino;R. Lucchetti;S. Fais;M. Vomero;M. Olivieri;M. Di Franco;R. Priori;V. Riccieri;A. Sili Scavalli;R. Scrivo;C. Alessandri;F. Conti;A. Polimeni;G. Valesini

2017-01-01

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Abstract

P. gingivalis is a Gram-negative anaerobic bacterium usually located in the oral cavity, as component of microbiome. Next to the established association with oral cavity diseases, such as periodontitis and halitosis, in the last years a growing interest has been addressed to its implication in the development of autoimmune diseases, such as Rheumatoid Arthritis (RA). The ability of P. gingivalis to citrullinate peptides is the most relevant link with RA. Indeed, this bacterium has several virulence factors directly contributing to its chronic inflammation regardless of citrullination. Data from the literature demonstrated the ability of P. gingivalis in inducing the production of several inflammatory cytokines, such as TNF, IL6 and IL17, through the TLR signaling pathways.