HLA-G molecules and clinical outcome in Chronic Myeloid Leukemia
CAOCCI, GIOVANNI
First
;ORRU, SANDRO;Mulas, Olga;Trucas, Marcello;CARCASSI, CARLO;LA NASA, GIORGIOLast
2017-01-01
Abstract
The human leukocyte antigen-G (HLA-G) gene encodes a tolerogenic protein known to promote tumor immune-escape. We investigated HLA-G polymorphisms and soluble molecules (sHLA-G) in 68 chronic myeloid leukemia (CML) patients. Patients with G*01:01:01 or G*01:01:02 allele had higher value of sHLA-G compared to G*01:01:03 (109.2±39.5 vs 39.9±8.8 units/ml; p=0.03), and showed lower event free survival (EFS) (62.3% vs 90.0%; p=0.02). The G*01:01:03 allele was associated with higher rates and earlier achievement of deep molecular response (MR)(4.5) (100% vs 65%, median of 8 vs 58 months, p=0.001). HLA-G alleles with higher secretion of sHLA-G seem associated with lower EFS, possibly because of an inhibitory effect on the immune system. Conversely, lower levels of sHLA-G promoted achievement of MR(4.5), suggesting increased cooperation with immune system.File | Size | Format | |
---|---|---|---|
HLA-G molecules and clinical outcome in Chronic Myeloid Leukemia.pdf Solo gestori archivio
Type: versione editoriale
Size 303.65 kB
Format Adobe PDF
|
303.65 kB | Adobe PDF | & nbsp; View / Open Request a copy |
LR-D-17-00161R1-3_merged.pdf open access
Type: versione pre-print
Size 1.31 MB
Format Adobe PDF
|
1.31 MB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.