Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people
TOMASSINI BARBAROSSA, IOLE;MELIS, MELANIA;
2017-01-01
Abstract
Deeper understanding of signaling mechanisms underlying bitterness perception in people is essential for designing novel and effective bitter blockers, which could enhance nutrition and compliance with orally administered bitter-tasting drugs. Here we show that variability in a human odorant-binding protein gene, OBPIIa, associates with individual differences in bitterness perception of fat (oleic acid) and of a prototypical bitter stimulus, 6-n-propylthiouracil (PROP), suggesting a novel olfactory role in the modulation of bitterness sensitivity.File | Size | Format | |
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Tomassini Barbarossa et al. 2017.pdf Solo gestori archivio
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