Synthesis and in vitro antiproliferative activity of new adamantylthiazolyl-1,3,4-oxadiazoles

LODDO, ROBERTA;
2009-01-01

Abstract

A new series of adamantanyl-1,3-thiazole and 1,3,4-oxadiazole derivatives (6a-l), bearing various aryl groups has been synthesized from adamantan-1-nitrile in four steps. All the compounds were evaluated, in vitro, for antiproliferative activity against a large panel of human tumor-derived cell lines. Compounds 6e exhibited activity against human splenic B-lymphoblastoid (WIL-2NS) and human acute B-lymphoblastic leukemia (CCRF-SB) cell lines with CC50 = 68 and 42 μM, respectively. Compound 61 showed activity against CCRF-SB cell lines with CC50 = 51 μM. All the other compounds were found inactive.
2009
Inglese
ARKIVOC
2009
11
85
93
9
WOS:000271148800008
2-s2.0-77949871457
Esperti anonimi
internazionale
scientifica
Adamantan-1-nitrile; Anti-HIV activity; Antitumor activity; Oxadiazoles; Thiazole
sì
Zahid, M; Yasin, Ka; Akhtar, T; Rama, Nh; Hameed, S; AL MASOUDI, Na; Loddo, Roberta; AND LA COLLA, P.
1.1 Articolo in rivista
info:eu-repo/semantics/article
1 Contributo su Rivista::1.1 Articolo in rivista
262
8
reserved
Files in This Item:
File Size Format  
Zahid, La Colla.pdf

Solo gestori archivio

Type: versione editoriale
Size 1.81 MB
Format Adobe PDF
& nbsp; View / Open   Request a copy
1.81 MB Adobe PDF & nbsp; View / Open   Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Questionnaire and social

Share on:
Impostazioni cookie