University of Cagliari
Interest of 3-arylcoumarins as xanthine oxidase inhibitors
PINTUS, FRANCESCA;DI PETRILLO, AMALIA
2015-01-01
Abstract
In the current paper we studied the interest of a series of 3-arylcoumarin derivatives as xanthine oxidase inhibitors. For the best compound of the series, the 4'-methoxyphenyl-6-nitrocoumarin, it was determined the IC50 value and the type of inhibition. This work is a preliminary screening for further design and synthetize new non-purinergic derivatives as potential compounds involved in the inflammatory suppression, specially related to the gout.
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