New Opioid Designed Multiple Ligand from Dmt-Tic and Morphinan Pharmacophores

NEUMEYER J. L;PENG X;KNAPP B. I;BIDLACK J. M;LAZARUS L. H;SALVADORI S;TRAPELLA C;BALBONI, GIANFRANCO

2006-01-01

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Abstract

Here, we report the synthesis of a designed multi-pharmacophore ligand derived from the linkage of a delta selective peptide antagonist (Dmt-Tic) and a mu/kappa morphinan agonist butorphan (MCL 101) through a two methylene spacer. The new compound MCL 450 maintains the same characteristics as those the two reference compounds. MCL 450 represents a useful starting point for the synthesis of other multiple opioid ligands endowed with analgesic properties with low tolerance and dependence.