Metabolomic approach to profile functional and metabolic changes in heart failure

DEIDDA, MARTINO;PIRAS, CRISTINA;CADEDDU DESSALVI, CHRISTIAN;LOCCI, EMANUELA;BARBERINI, LUIGI;TORRI, FEDERICA;ASCEDU, FEDERICA;ATZORI, LUIGI;MERCURO, GIUSEPPE

2015-01-01

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Abstract

Heart failure (HF) is characterized by a series of adaptive changes in energy metabolism. The use of metabolomics enables the parallel assessment of a wide range of metabolites. In this study, we appraised whether metabolic changes correlate with HF severity, assessed as an impairment of functional contractility, and attempted to interpret the role of metabolic changes in determining systolic dysfunction.