Design, synthesis, and anti-HIV-1 activity of 1-substituted 3-(3,5-dimethylbenzyl)triazine derivatives

Sakakibara, Norikazu;BALBONI, GIANFRANCO;CONGIU, CENZO;ONNIS, VALENTINA;Demizu, Yosuke;Misawa, Takashi;Kurihara, Masaaki;Kato, Yoshihisa;Maruyama, Tokumi;Toyama, Masaaki;Okamoto, Mika;Baba, Masanori

2015-01-01

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Abstract

The reverse transcriptase (RT) of human immunodeficiency virus type 1 (HIV-1) is an attractive target for the development of drugs used in the treatment of HIV-1 infection and acquired immune deficiency syndrome (AIDS). We have continued the search for novel anti-HIV-1 agents using the structure-activity relationships of the successful 1,3-disubstituted and 1,3,6-trisubstituted uracil-type HIV-1 RT inhibitors.